276254-77-4Relevant academic research and scientific papers
Synthesis and anticonvulsant activity of 5-aryl-1,3,4-thiadiazole derivatives
Foroumadi,Tabatabai,Gitinezhad,Zarrindast,Shafiee
, p. 31 - 33 (2007/10/03)
5-Aryl-1,3,4-thiadiazole derivatives were synthesized and tested for anticonvulsant activity using the pentylenetetrazole-induced lethal convulsion test. The results showed that 2-amino derivatives have anticonvulsant activity (LD50 > 500 mg kg-1) and this effect was not mediated through benzodiazepine receptors. The fluoro electron-withdrawing substituent on the phenyl ring did not potentiate the activity of the compounds.
