27639-72-1Relevant academic research and scientific papers
Synthesis and anti-tumor evaluation of new trisulfide derivatives
An, Haoyun,Zhu, Jenny,Wang, Xiaobo,Xu, Xiao
, p. 4826 - 4829 (2006)
New bis-aromatic and heterocyclic trisulfide derivatives 5, 7-10 were synthesized by optimizing lead dibenzyl trisulfide natural product (4) to evaluate their anti-tumor activities. Five compounds 5-7, 9, and 10 exhibited potent anti-tumor activities against eight different tumor cell lines with low cytotoxicity against HepG2. Initial SAR was discussed, and MOA of these anti-microtubule agents was suggested based on cell kinetic response patterns observed on RT-CES system.
Substituted organosulfur compounds and methods of using thereof
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Page/Page column 9-10, (2008/06/13)
The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative disorder. The present invention also provides methods for preparing trisulfide compounds and compositions.
