2764-03-6

Usage

Uses

Used in Cosmetic and Personal Care Industry:
Glycine linoleamide is used as an emollient and skin conditioning agent for its ability to moisturize and nourish the skin, improving the skin's barrier function. It is particularly effective in softening and smoothing the skin, making it a common ingredient in moisturizers, lotions, and other skincare products.
Used in Skincare Formulations:
Glycine linoleamide is used as an active ingredient for its anti-inflammatory and antioxidant effects, contributing to the improvement of skin health and appearance. Its inclusion in skincare products helps to soothe inflammation and protect the skin from oxidative stress, promoting a healthier and more youthful complexion.

InChI:InChI=1/C20H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19(22)21-18-20(23)24/h6-7,9-10H,2-5,8,11-18H2,1H3,(H,21,22)(H,23,24)/b7-6-,10-9-

Upstream product

• 60-33-3 linoleic acid 
• 56-40-6 glycine 
• 69888-88-6 N-succinimidyl cis,cis-9,12-octadecadienoate 

Relevant academic research and scientific papers

Preparation method and application of compound with beta amyloid protein resisting activity

The present invention provides a compound represented by formula I, or a pharmaceutically acceptable salt thereof. The invention also provides a preparation method of the compound. Experimental results show that the compound is suitable for industrial pro

Improvements in or Relating to Organic Compounds

A stock solution comprising a compound of formula (I) Wherein R1 together with the carbonyl group to which it is attached is a residue of a carboxylic acid, and NR2R3, in which R3 is H or together with R2 and the N-atom to which they are attached, a 5-membered ring, is a residue of an amino acid, in particular a proteinogenic amino acid, ornithine, gamma-aminobutyric acid or beta alanine, or a 1-amino cycloalkyl carboxylic acid.

Evaluation of endogenous fatty acid amides and their synthetic analogues as potential anti-inflammatory leads

A series of endogenous fatty acid amides and their analogues (1-78) were prepared, and their inhibitory effects on pro-inflammatory mediators (NO, IL-1β, IL-6, and TNF-α) in LPS-activated RAW264.7 cells were evaluated. Their inhibitory activity on the pro-inflammatory chemokine MDC in IFN-γ-activated HaCaT cells was also examined. The results showed that the activity is strongly dependent on the nature of the fatty acid part of the molecules. As expected, the amides derived from enone fatty acids showed significant activity and were more active than those derived from other types of fatty acids. A variation of the amine headgroup also altered bioactivity profile remarkably, possibly by modulating cell permeability. Regarding the amine part of the molecules, N-acyl dopamines exhibited the most potent activity (IC50 ～2 μM). This is the first report of the inhibitory activity of endogenous fatty acid amides and their analogues on the production of nitric oxide, cytokines (IL-1β, IL-6, and TNF-α) and the chemokine MDC. This study suggests that the enone fatty acid-derived amides (such as N-acyl ethanolamines and N-acyl amino acids) and N-acyl dopamines may be potential anti-inflammatory leads.