2764-43-4

Usage

InChI:InChI=1/C8H15NO2/c1-3-11-8(10)7-5-4-6(2)9-7/h6-7,9H,3-5H2,1-2H3

Upstream product

• 73472-94-3 ethyl 3-bromo-2-(hydroxyimino)propanoate 
• 66183-71-9 ethyl 2-oxopyrrolidine-5-carboxylate 
• 149-87-1 Pyroglutamic acid 
• 100911-28-2 5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylic acid ethyl ester 
• 251924-83-1 1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate 

Downstream Products

• 1621482-39-0 1-benzyl 2-ethyl 5-methylpyrrolidine-1,2-dicarboxylate 
• 1621483-00-8 tert-butyl 2-((S)-1-((4-fluorobenzyl)amino)-3-hydroxy-1-oxopropan-2-yl)-1,6-dimethyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 
• 1621482-98-1 tert-butyl 2-((2S,3R)-1-(tert-butylamino)-3-hydroxy-1-oxobutan-2-yl)-1,6-dimethyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 
• 1621482-96-9 tert-butyl 2-((2S,3R)-3-hydroxy-1-(isopropylamino)-1-oxobutan-2-yl)-1,6-dimethyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 
• 1621482-94-7 tert-butyl 2-((2S,3R)-3-hydroxy-1-((4-methoxybenzyl)amino)-1-oxobutan-2-yl)-1,6-dimethyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 
• 1621482-92-5 tert-butyl 2-((2S,3R)-1-((4-fluorobenzyl)amino)-3-hydroxy-1-oxobutan-2-yl)-1,6-dimethyl-3-oxo-2.5-diazaspiro[3.4]octane-5-carboxylate 
• 1621482-90-3 tert-butyl 2-((2S,.3R)-1-(benzylamino)-3-hydroxy-1-oxobutan-2-yl)-1,6-dimethyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 
• 1621482-87-8 (2S)-2-(5-(tert-butoxycarbonyl)-1,6-dimethyl-3-oxo-2,5-diazaspiro[3.4]octan-2-yl)-3-hydroxypropanoic acid 
• 1621482-85-6 tert-butyl 2-((S)-1,3-bis(benzyloxy)-1-oxopropan-2-yl)-1,6-dimethy-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 
• 1621482-82-3 tert-butyl 2-(((S)-1,3-bis(benzyloxy)-1-oxopropan-2-yl)carbamoyl)-2-(1-hydroxyethyl)-5-methylpyrrolidine-1-carboxylate 
• 1621482-75-4 tert-butyl 2-((2S,3R)-3-(benzyloxy)-1-oxo-1-(pyrrolidin-1-yl)butan-2-yl)-1,6-dimethyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 
• 1621482-73-2 tert-buty 2-(((2S,3R)-3-(benzyloxy)-1-oxo-1-(pyrrolidin-1-yl)butan-2-yl)carbamoyl)-2-(1-hydroxyethyl)-5-methylpyrrolidine-1-carboxylate 
• 1621482-67-4 tert-butyl 2-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-1,6-dimethyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 
• 1621436-10-9 tert-butyl 2-((2S,3R)-3-(benzyloxy)-1-oxo-1-(pyrrolidin-1-yl)butan-2-yl)-6-methyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 

Relevant academic research and scientific papers

SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed are compounds having enhanced potency in the modulation of NMD A receptor activity. Such compounds are contemplated for use in the treatment of conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed are compounds having enhanced potency in the modulation of NMD A receptor activity. Such compounds are contemplated for use in the treatment of conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

Reduction of Ethyl 5,6-Dihydro-4H-1,2-oxazine-3-carboxylates. A Route to Proline Ethyl Ester and Other Ethyl Pyrrolidine-2-carboxylates

The title dihydro-oxazines, which are formed by cycloaddition of ethyl 2-nitrosopropenoate to nucleophilic alkenes, are reductively cleaved by reaction with aluminium amalgam and by hydrogenation over palladium in the presence of triethyl borate.The produ