27646-78-2

Usage

Uses

Used in Organic Synthesis:
2-(METHYLAMINO)-1-PROPANOL is used as a reagent in organic synthesis for its ability to act as a building block in the creation of various chemical compounds.
Used in Pharmaceutical and Agrochemical Production:
2-(METHYLAMINO)-1-PROPANOL is used as a building block for the production of various pharmaceuticals and agrochemicals due to its versatile chemical properties.
Used in Surfactant and Wetting Agent Manufacturing:
2-(METHYLAMINO)-1-PROPANOL is used as an intermediate in the manufacturing of surfactants and wetting agents, contributing to the development of these products.
Used in Herbicide, Pesticide, and Dye Production:
2-(METHYLAMINO)-1-PROPANOL is used in the production of herbicides, pesticides, and dyes, highlighting its broad range of applications across different industries.
Safety Considerations:
2-(METHYLAMINO)-1-PROPANOL is considered to be relatively stable under normal conditions but should be handled with caution due to its potential to cause skin and eye irritation upon contact.

InChI:InChI=1/C4H11NO/c1-4(3-6)5-2/h4-6H,3H2,1-2H3

Upstream product

• 600-21-5 N-methylalanine 
• 170749-86-7 2-(N-benzyl-N-methylamino)propan-1-ol 
• 56428-90-1 ethyl-α-methylaminopropionate 
• 34101-08-1 N-ethylthiothioxomethyl-L-alanine 
• 3913-67-5 N-methylalanine 
• 32221-83-3 (S)-N-formylalanine methyl ester 
• 5893-10-7 (S)-2-formamidopropanoic acid 
• 35023-55-3 N-methyl-L-alanine methyl ester 

Downstream Products

• 95421-91-3 (S)-AlaNOP 
• 573701-30-1 (2S)-2-[benzyl(methyl)amino]propan-1-ol 

Relevant academic research and scientific papers

4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS

The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

3,3-DISUBSTITUTED-1-HYDROXYTRIAZ-1-ENE 2-OXIDES AND WOUND-HEALING COMPOSITIONS USING THEM

Esters, carbonates and imides of 3,3-disubstituted-1-hydroxytriaz-1-ene 2-oxides of the formula I are disclosed. The compounds release nitric oxide (NO) under physiologic conditions, and pharmaceutical compositions containing them are useful to aid in wound healing.

NO-RELEASING NONOATE(OXYGEN-BOUND)CHROMENE CONJUGATES

The present invention provides NO-releasing NONOate(oxygen bound)chromene conjugates, having the structure of Formula (I): wherein Z, R1, R2, R3, R4, R5, R6, and R7 are as defined in the detailed description; pharmaceutical compositions comprising at least one compound of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis, or acne, using a compound of Formula (I).

2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS

The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.

Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction

The second-generation synthesis of 3′-hydroxypacidamycin D (2) has been accomplished via an Ugi-four component reaction at a late stage of the synthesis. This approach provided ready access to a range of analogues including diastereomers of the diaminobut

Catalytic Hydrogenation of Chiral α-Amino and α-Hydroxy Esters at Room Temperature with Nishimura Catalyst without Racemization

The hydrogenation of carboxylic acid derivatives at room temperature was investigated. With a mixed Rh/Pt oxide (Nishimura catalyst), low to medium activity was observed for various α-amino and α-hydroxy esters. At 100 bar hydrogen pressure and 10% catalysts loading, high yields of the desired amino alcohols and diols were obtained without racemization. The most suitable α-substituents were NH2, NHR, and OH, whereas β-NH2 were less effective. Usually, aromatic rings were also hydrogenated, but with the free bases of amino acids as substrates, some selectivity was observed. No reaction was found for α-NR2, α-OR, and unfunctionalized esters; acids and amides were also not reduced under these conditions. A working hypothesis for the mode of action of the catalyst is presented.

Enantioselective reduction of aromatic ketones catalysed by chiral ruthenium(II) complexes

The catalytic enantioselective reduction of aromatic ketones in 2- propanol is carried out by using ruthenium(II) complexes prepared from [Ru(p- cymene)Cl2]2 and a variety of chiral diamines and β-aminoalcohols derived from α-amino acids. Good conversions (>99%) and enantioselectivities (=96%) are observed under mild reaction conditions. (C) 2000 Elsevier Science Ltd.

α-Amino Acids as Chiral Educts for Stereoselective Syntheses of Pyrrolidine and Pyrrolizidine Systems

Homochiral functionalized pyrrolidine and pyrrolizidine systems have been achieved by stereoselective intramolecular 1,3-dipolar cycloaddition of homochiral nitrones, starting from homochiral amino acids, and by subsequent reduction of the obtained cycloadducts.

SYNTHESE D'AMINOPHOSPHINEPHOSPHINITES CHIRAUX. UTILISATION EN REDUCTION ASYMETRIQUE CATALYTIQUE

The chiral aminophosphinephosphinites ligands (AMPP) are directly synthesized from natural amino alcohols or by reduction of formyl esters of α-amino acids and PPh2Cl. Their cationic rhodium complexes have been found to be excellent catalysts for enantioselective hydrogenation of dehydroamino acids (ee ca. 86percent, yield ca. 100percent) for example.Asymmetric reduction of ketones can also be performed with the new alkyl AMPP* modified rhodium catalyst (ee 50percent).