32221-83-3Relevant academic research and scientific papers
Capsicum annuum fruit extract: A novel reducing agent for the green synthesis of zno nanoparticles and their multifunctional applications
Lalithamba, Haraluru Shankraiah,Raghavendra, Mahadevaiah,Uma, Kogali,Yatish, Kalanakoppal Venkatesh,Mousumi, Das,Nagendra, Govindappa
, p. 354 - 364 (2018/07/05)
A simple, efficient and convenient method for the preparation of zinc oxide (ZnO) nanoparticle was described. Several parameters like size and morphology of the prepared nanoparticles were characterized thorough a variety of analytical techniques such as
Iron-catalyzed peroxidation-carbamoylation of alkenes with hydroperoxides and formamides: Via formyl C(sp2)-H functionalization
Cheng, Jun-Kee,Shen, Liang,Wu, Liu-Hai,Hu, Xu-Hong,Loh, Teck-Peng
supporting information, p. 12830 - 12833 (2017/12/06)
A reaction protocol in which FeCl3 and tert-butyl hydroperoxide facilitated a selective radical coupling reaction of aryl alkenes or 1,3-enynes with tert-butyl hydroperoxide and formamides to prepare an array of β-peroxy amides has been achieved. The β-peroxy amide could serve as a synthetic precursor which was facilely converted to β-hydroxy amide, β-keto amide and β-lactam following subsequent chemical transformation.
Formamide Synthesis through Borinic Acid Catalysed Transamidation under Mild Conditions
Mohy El Dine, Tharwat,Evans, David,Rouden, Jacques,Blanchet, Jér?me
supporting information, p. 5894 - 5898 (2016/04/26)
A highly efficient and mild transamidation of amides with amines co-catalysed by borinic acid and acetic acid has been reported. A wide range of functionalised formamides was synthesized in excellent yields, including important chiral α-amino acid derivatives, with minor racemisation being observed. Experiments suggested that the reaction rely on a cooperative catalysis involving an enhanced boron-derived Lewis acidity rather than an improved Br?nsted acidity of acetic acid. Amide bonds are reputedly difficult to activate due to their high resonance stabilization. An unusual mild activation of dimethylformamide and formamide by borinic acid 1 (see scheme), illustrated by a general formylation of a wide range of amines, including chiral α-amino esters, has been reported.
Effective Formylation of Amines with Carbon Dioxide and Diphenylsilane Catalyzed by Chelating bis(tzNHC) Rhodium Complexes
Nguyen, Thanh V. Q.,Yoo, Woo-Jin,Kobayashi
supporting information, p. 9209 - 9212 (2015/08/06)
The reductive formylation of amines using CO2 and hydrosilanes is an attractive method for incorporating CO2 into valuable organic compounds. However, previous systems required either high catalyst loadings or high temperatures to achieve high efficiency, and the substrate scope was mostly limited to simple amines. To address these problems, a series of alkyl bridged chelating bis(NHC) rhodium complexes (NHC=N-heterocyclic carbene) have been synthesized and applied to the reductive formylation of amines using CO2 and Ph2SiH2. A rhodium-based bis(tzNHC) complex (tz=1,2,3-triazol-5-ylidene) was identified to be highly effective at a low catalyst loading and ambient temperature, and a wide substrate scope, including amines with reducible functional groups, were compatible. Beyond the norm: Rhodium complexes bearing a strong electron-donating bis(1,2,3-triazol-5-ylidene) ligand were found to be excellent catalysts for the reductive formylation of amines with CO2 and Ph2SiH2 at ambient temperature. The catalyst system possesses a broad substrate scope which tolerates a variety of reducible functional groups and is suitable for the synthesis of bioactive compounds. Tf=trifuoromethanesulfonyl.
ENOPEPTINS, USES THEREOF, AND METHODS OF SYNTHESIS THERETO
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Page/Page column 76, (2012/10/18)
Provided herein are inventive enopeptin compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Further provided are methods of preparation, use, and treatment.
A remarkably simple protocol for the N -formylation of amino acid esters and primary amines
Suchy, Mojmir,Elmehriki, Adam A. H.,Hudson, Robert H. E.
supporting information; experimental part, p. 3952 - 3955 (2011/09/19)
A simple, convenient, and wide scope protocol for the N-formylation of amino acid esters and primary amines has been developed utilizing only imidazole in warm DMF.
Investigation of the configurational stabilities of chiral isocyanoacetates in multicomponent reactions
Carney, Daniel W.,Truong, Jonathan V.,Sello, Jason K.
experimental part, p. 10279 - 10285 (2012/02/14)
Isocyanoacetates are uniquely reactive compounds characterized by an ambivalent isocyano functional group and an enolizable α-carbon. It is widely believed that chiral α-substituted isocyanoacetates are configurationally unstable in some synthetically use
Diversity-oriented synthesis of cyclic acyldepsipeptides leads to the discovery of a potent antibacterial agent
Socha, Aaron M.,Tan, Nicholas Y.,Laplante, Kerry L.,Sello, Jason K.
experimental part, p. 7193 - 7202 (2010/12/25)
A class of cyclic acyldepsipeptide antibiotics collectively known as the enopeptins has recently attracted much attention because of their activity against multidrug-resistant bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. These antibiotics are further distinguished by their novel mechanism of action in which they bind and deregulate the tightly controlled activity of the cytoplasmic protease ClpP. Although the natural products have poor pharmacological properties, a synthetic derivative called acyldepsipeptide 4 (ADEP 4) showed remarkable antibacterial activity both in vitro and in mouse models of bacterial infections. A novel route to the ADEP 4 peptidolactone core structure, featuring the Joullié-Ugi three-component reaction, was developed. This multicomponent reaction and a related multicomponent reaction, the Ugi four-component reaction, were used to prepare analogs that were designed using the principles of conformational analysis. These cyclic acyldepsipeptides were tested for their activity against drug-resistant, clinical isolates of Staphylococci and Enterococci. One ADEP 4 analog in which the pipecolate was replaced by 4-methyl pipecolate exhibited in vitro antibacterial activity against Enterococci that was fourfold higher than the parent compound.
Isoselenocyanates derived from amino acid esters: An expedient synthesis and application to the assembly of selenoureidopeptidomimetics, unsymmetrical Selenoureas and selenohydantoins
Hemantha, Hosahalli P.,Sureshbabu, Vommina V.
scheme or table, p. 644 - 651 (2011/09/14)
An important class of organoselenium compounds-α-isoselenocyanato esters 4 hasbeen prepared by a reaction of α-isocyano esters with elemental selenium powder. The reaction issimple, rapid and all the isoselenocyanates havebeen isolated as stable ones after chromatographic purification. These hitherto unreported classes of molecules would be useful building blocks for the preparation of variety of selenium containing peptidomimetics. In this study, the utility of the title molecules in the preparation of selenoureidopeptidomimetics 6, unsymmetrical selenoureas 8 and selenohydantoins 10 isdemonstrated.
Environmentally benign process for the synthesis of N-formyl amino acid esters
Kotha, Sambasivarao,Behera, Manoranjan,Khedkar, Priti
, p. 7589 - 7590 (2007/10/03)
Several amino acid ester hydrochlorides were reacted with ammonium formate to give N-formyl amino acid esters in good yields.
