27655-93-2

Upstream product

• 15174-47-7 α-methyl-trans-cinnamaldehyde 
• 58550-28-0 (2E,4E)-ethyl 4-methyl-5-phenylpenta-2,4-dienoate 
• 100-52-7 benzaldehyde 
• 148904-71-6 (2-methyl-3-phenyl-allylidene)-malonic acid 
• 18795-82-9 2-propylidene malonic acid dimethyl ester 
• 77182-91-3 (2Z,4E)-4-methyl-5-phenylpenta-2,4-dienoic acid 

Downstream Products

• 37580-42-0 (E)-2-methyl-1-phenyl-1,3-butadiene 
• 406725-16-4 (2E,4E)-6-(4-Methyl-5-phenylpenta-2,4-dienoylamino)-hexanoic acid methyl ester 

Relevant academic research and scientific papers

Palladium-Catalyzed Chemoselective Protodecarboxylation of Polyenoic Acids

Conditions for the first palladium-catalyzed chemoselective protodecarboxylation of polyenoic acids to give the desired polyenes in good yields are presented. The reactions proceed under mild conditions using either a Pd(0) or Pd(II) catalyst and tolerate a variety of aryl and aliphatic substitutions. Unique aspects of the reaction include the requirement of phosphines, water, and a polyene adjacent to the carboxylic acid.

cis-Cinnamic acid selective suppressors distinct from auxin inhibitors

The activity of cis-cinnamic acid (cis-CA), one of the allelochemicals, in plants is very similar to that of indole-3-acetic acid (IAA), a natural auxin, and thus cis-CA has long been believed to be an analog of auxin. We have reported some structure-acti

Histone deacetylase inhibitors

Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, inclu

A tentative descriptive modelling of chemical structure-biological activity relationships. Biological evaluation of a series of polyethylenic acids

48 new polyethylenic-malonic acids have been submitted to an antimicrobial and antifungal screening. After a suitable recoding, the experimental results were analyzed according to two mathematical multivariate analysis using a computer process i.e. Correspondence Factorial Analysis and Cluster Analysis. These methods allowed an accurate study of the structure of the system and a thorough investigation of the structure-activity-specificity relationships. On the other side, magnitude and/or specificity of the observed biological effects were related to structural features. These results should be useful in order to elaborate synthetic strategies.