276677-03-3

Upstream product

• 5469-19-2 1-bromo-2,4,5-trimethylbenzene 
• 88111-74-4 bromo-4 dimethyl-2,5 benzaldehyde 
• 292037-85-5 4-bromo-2,5-dimethylbenzonitrile 
• 7697-37-2 nitric acid 
• 95-63-6 1,2,4-Trimethylbenzene 
• 824-45-3 2,5-dimethylbenzyl chloride 
• 108480-48-4 4-bromo-2,5-dimethylbenzyl chloride 
• 1074-24-4 2,5-dibromo-p-xylene 
• 110-05-4 di-tert-butyl peroxide 
• 7697-28-1 4-bromo-3-methylbenzoic acid 

Downstream Products

• 858489-42-6 4-bromo-2,5-dimethyl-3,6-dinitro-benzoic acid 
• 276677-04-4 4-bromo-2-ethoxycarbonylmethyl-5-methyl-benzoic acid 
• 276678-65-0 4-bromo-2.5-dimethylbenzoic acid chloride 
• 854663-04-0 3-bromo-1,4-dimethyl-2,5-dinitro-benzene 
• 856352-10-8 2-bromo-3,6-dimethyl-aniline 
• 52415-02-8 2-bromo-1,4-dimethyl-3-nitro-benzene 
• 26829-89-0 2,4-dibromo-3,6-dimethylaniline 

Relevant academic research and scientific papers

Preparation method for o-tolylacetic acid aryl formic acid derivative

The invention discloses a preparation method for an o-tolylacetic acid aryl formic acid derivative. According to the method, new C-C bonds can be formed, the organic o-tolylacetic acid aryl formic acid derivative is obtained, the good functional group tolerance is achieved, and the o-tolylacetic acid aryl formic acid derivative which cannot be easily obtained by adopting other methods can be synthesized; according to the method, adopted raw materials are easy to obtain, the yield is high, the reaction conditions are mild, the substrate range is wide, and after-treatment is simple and green.

Palladium-Catalyzed ortho-C-H Methylation of Benzoic Acids

A palladium-catalyzed methylation of C-H bonds of benzoic acids with di-tert-butyl peroxide as the methylating reagent under an external oxidant and ligand-free conditions has been achieved. The reaction is found to be directed by a weakly coordinating carboxyl group, offering a facile route for the synthesis of highly functionalized ortho-methyl benzoic acids.