5469-19-2

Basic information

• Product Name: 5-BROMO-1,2,4-TRIMETHYLBENZENE
• Synonyms: 1-Bromo-2,4,5-trimethylbenzene;5-BROMO-1,2,4-TRIMETHYLBENZENE;5-BROMOPSEUDOCUMENE;2,4,5-TRIMETHYLBROMOBENZENE;5-BROMO-1 2 4-TRIMETHYLBENZENE 99%;5-Bromo-1,2,4-trimethylbenzene,99%;1,2,4-Trimethyl-5-bromobenzene;Benzene,1-broMo-2,4,5-triMethyl-
• CAS NO: 5469-19-2
• Molecular Formula: C₉H₁₁Br
• Molecular Weight: 199.09
• EINECS: 226-793-5
• Product Categories: Industrial/Fine Chemicals;Aryl;Building Blocks;C9 to C12;Chemical Synthesis;Halogenated Hydrocarbons;Organic Building Blocks
• Mol File: 5469-19-2.mol

Chemical Properties

• Melting Point: 70-73 °C
• Boiling Point: 233-235 °C
• Flash Point: 233-235°C
• Appearance: /
• Density: 1.2949 (estimate)
• Vapor Pressure: 0.0818mmHg at 25°C
• Refractive Index: 1.5482 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-BROMO-1,2,4-TRIMETHYLBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-1,2,4-TRIMETHYLBENZENE(5469-19-2)
• EPA Substance Registry System: 5-BROMO-1,2,4-TRIMETHYLBENZENE(5469-19-2)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 5469-19-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-1,2,4-trimethylbenzene is used as an intermediate in the synthesis of Coenzyme Qn2, a derivative of Coenzyme Q10. Coenzyme Q10 is an essential component in the mitochondrial electron transport chain, playing a crucial role in cellular energy production. It has been widely used in the pharmaceutical industry for its potential benefits in treating various conditions, such as heart disease, neurodegenerative disorders, and as an antioxidant.
Used in Chemical Synthesis:
5-Bromo-1,2,4-trimethylbenzene is also used as a starting material in the preparation of 4-trimethylbenzoic acid, which is an important intermediate in the synthesis of various organic compounds and pharmaceuticals. The bromine atom in the compound can be replaced with other functional groups through chemical reactions, making it a versatile building block for the synthesis of a wide range of organic molecules.

InChI:InChI=1/C9H11Br/c1-6-4-8(3)9(10)5-7(6)2/h4-5H,1-3H3

Upstream product

• 95-63-6 1,2,4-Trimethylbenzene 
• 137-17-7 2,4,5-trimethylaniline 
• 3453-84-7 2,4,5-trimethylbenzenesulfonic acid 
• 56403-26-0 1-bromo-2,5-bis(chloromethyl)-4-methylbenzene 
• 7726-95-6 bromine 
• 7697-37-2 nitric acid 
• 7732-18-5 water 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 636-28-2 1,2,4,5-tetrabromobenzene 
• 74-88-4 methyl iodide 
• 106-38-7 para-bromotoluene 

Downstream Products

• 17851-27-3 1-ethyl-2,4,5-trimethylbenzene 
• 90326-72-0 1,2,4-tribromo-3,5,6-trimethyl-benzene 
• 82940-81-6 3-bromo-2,4,5-trimethylbenzenesulfonic acid 
• 41381-36-6 2-bromo-1,3,4-trimethyl-benzene 
• 5877-60-1 1-bromo-2,4,5-trimethyl-3,6-dinitro-benzene 
• 842136-27-0 5-bromo-2,4-dimethylbenzoic acid 
• 276677-03-3 4-bromo-2,5-dimethylbenzoic acid 
• 133833-71-3 tris-(2,4,5-trimethyl-phenyl)-phosphine 
• 56457-45-5 bis-(2,4,5-trimethyl-phenyl)-mercury 
• 95-93-2 1,2,4,5-tetramethylbenzene 
• 154152-57-5 4-bromo-3-nitro-1,2,5-trimethylbenzene 
• 5779-72-6 2,4,5-trimethylbenzaldehyde 
• 528-90-5 2,4,5-trimethylbenzoic acid 
• 159277-49-3 1',2'-Dideoxy-1'-(1,2,4-trimethylphenyl)-3',5'-di-O-toluoyl-β-D-ribofuranose 

Relevant articles and documents

Carboxy-substituted phthalocyanine metal complexes

Metal complexes of carboxy-substituted phthalocyanines differing in the number of carboxy groups and their positions and those having carboxy groups together with other substituents were synthesized, and their spectral and some other properties were studied. 2005 Pleiades Publishing, Inc.

Method for synthesizing trimethylhydroquinone through pseudocumene

The invention relates to a method for synthesizing trimethylhydroquinone through pseudocumene. The method for synthesizing the trimethylhydroquinone through the pseudocumene comprises the following steps that the pseudocumene is used as the raw material, a brominating reaction, an oxidizing reaction and a reduction reaction are conducted, and finally the trimethylhydroquinone is prepared. Please see the reaction formula in the specifications. According to the method for synthesizing the trimethylhydroquinone through the pseudocumene, the low-cost pseudocumene is used as the starting raw material, the process route is short, the yield is high, complete cyclic utilization of the bromine element can be achieved through recycling, the method for synthesizing the trimethylhydroquinone through the pseudocumene is a clean synthesizing technology, and the problems that in the prior art, m-cresol is in short supply, and serious pollution is caused in the p-xylene technology are solved.

Fast and efficient bromination of aromatic compounds with ammonium bromide and Oxone

A highly efficient, rapid and regioselective protocol was developed for the ring bromination of aromatic compounds under mild conditions with ammonium bromide as a source of bromine source and Oxone (potassium peroxysulfate) as an oxidant. No metal catalyst or acidic additive is required. A variety of aromatic compounds, including methoxy, hydroxy, amino, and alkyl arenes, reacted smoothly to give the corresponding monobrominated products in good to excellent yields in very short reaction times. Moreover, dibromination of deactivated anilines to give the corresponding dibromides proceeded in high yields. Interestingly, 1-(2-naphthyl)ethanone provided a ring-brominated product. Georg Thieme Verlag Stuttgart . New York.

Bromination of aromatic compounds using ammonium bromide and oxone

A simple, efficient and mild method for the selective bromination of activated aromatic compounds using ammonium bromide as the source of bromine and Oxone as the oxidant in methanol or water as solvent is reported. The reaction proceeds at ambient temperature in yields ranging from moderate to excellent without a catalyst. Georg Thieme Verlag Stuttgart.

Induced bromination of aromatic hydrocarbons by alkali metals bromides and sodium hypochlorite

Induced bromination of aromatic compounds in a system MBr-acid-NaOCl was studied. Optimum conditions of the process were developed, kinetics of the reactions were investigated, and the process mechanism was suggested. The bromination occurs both with the bromine in statu nascendi and with the hypobromous acid by hydrogen substitution exclusively in the aromatic ring. 2005 Pleiades Publishing, Inc.

Novel bromination method for anilines and anisoles using NH 4Br/H2O2 in CH3COOH

A simple, efficient, regioselective, environmentally safe, and economical method for the oxybromination of anilines and anisoles without catalyst is reported. The electrophilic substitution of bromine generated in situ from ammonium bromide as a bromine source and hydrogen peroxide as an oxidant for the first time.