27677-53-8Relevant academic research and scientific papers
A simple and convenient two-step, one-pot synthesis of hetero-imidazoles from nitroaminoaryls catalyzed by Ytterbium triflate
Wang, Fen,Tran-Dubé, Michelle,Scales, Stephanie,Johnson, Sarah,McAlpine, Indrawan,Ninkovic, Sacha
, p. 4054 - 4057 (2013/07/25)
A mild two-step one-pot procedure for the conversion of ortho-nitroamino aromatic heterocycles into corresponding benzo and heteroaromatic fused imidazoles is described. The procedure utilizes iron powder, acetic acid, triethylorthoformate, and a catalytic amount of Ytterbium triflate at 75 C for the nitro group reduction and cyclization reaction. The optimum stoichiometry of each component is highlighted and the broad utility is demonstrated with high compatibility to numerous functional groups.
Use of the vinyl group as an efficient protecting group for azole N- atoms: Synthesis of polyfunctionalized imidazoles and thieno[2,3-d] ? [3,2-d]imidazole
Hartley, David J.,Iddon, Brian
, p. 4647 - 4650 (2007/10/03)
2,4,5-Tribromo-1-vinylimidazole was prepared from 2,4,5-tribromoimidazole and 1,2-dibromoethane and its Br-atoms were replaced regioselectively in the order 2 → 5 → 4 via Br → MgBr and other exchange reactions. Efficient removal of die vinyl groups from die resulting polyfunctionalized imidazoles was achieved with ozone or potassium permanganate. An extension of this methodology has allowed the first synthesis of thieno[2,3-d] ? [3,2-d]-imidazole.
SUBSTITUTED IMIDAZO-FUSED 5-MEMBERED RING HETEROCYCLES AND THEIR USE AS ANGIOTENSIN II ANTAGONISTS
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, (2008/06/13)
There are disclosed new substituted imidazo-fused 5-membered ring heterocyclic compounds and derivatives thereof which are useful as angiotensin II antagonists. These compounds have the general formula: STR1
