27683-60-9

Basic information

• Product Name: 2,2-Dichloro-1-(2-chlorophenyl)-1-ethanol
• Synonyms: 2-chloro-alpha-(dichloromethyl)benzyl alcohol;2,2-Dichloro-1-(2-chlorophenyl)ethanol;2-chloro-α-(dichloromethyl)benzyl alcohol;2,2-Dichloro-1-(2-chlorophenyl)-1-ethanol;2-Chloro-α-(dichloromethyl)benzenemethanol
• CAS NO: 27683-60-9
• Molecular Formula: C₈H₇Cl₃O
• Molecular Weight: 225.5
• EINECS: 248-601-9
• Mol File: 27683-60-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 311.9 °C at 760 mmHg
• Flash Point: 142.4 °C
• Appearance: /
• Density: 1.449 g/cm³
• Vapor Pressure: 0.000234mmHg at 25°C
• Refractive Index: 1.581
• PKA: 11.91±0.20(Predicted)
• CAS DataBase Reference: 2,2-Dichloro-1-(2-chlorophenyl)-1-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Dichloro-1-(2-chlorophenyl)-1-ethanol(27683-60-9)
• EPA Substance Registry System: 2,2-Dichloro-1-(2-chlorophenyl)-1-ethanol(27683-60-9)

Safety Data

• Hazardous Substances Data: 27683-60-9(Hazardous Substances Data)

Usage

General Description

2,2-Dichloro-1-(2-chlorophenyl)-1-ethanol, also known as triclosan, is a synthetic antimicrobial agent and preservative commonly used in personal care products, such as soaps, toothpaste, and cosmetics. It is a chlorinated aromatic compound with antibacterial and antifungal properties. Triclosan has been widely used for its ability to inhibit the growth of bacteria and fungi, and it is often added to products to prevent the spread of infections and maintain hygiene. However, there have been concerns about the potential impact of triclosan on human health and the environment, as it has been detected in water sources and recent studies have raised questions about its safety and effectiveness. As a result, triclosan has been banned or restricted in some countries.

InChI:InChI=1/C8H7Cl3O/c9-6-4-2-1-3-5(6)7(12)8(10)11/h1-4,7-8,12H

Upstream product

• 24123-67-9 2,2‐dichloro‐1‐(2‐chlorophenyl)ethan‐1‐one 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 75-09-2 dichloromethane 
• 89-98-5 2-chloro-benzaldehyde 
• 10291-39-1 2,2,2-trichloro-1-(2-chloro-phenyl)-ethanol 
• 36692-27-0 2-chlorophenylmagnesium bromide 
• 79-02-7 2,2-dichloroacetaldehyde 

Downstream Products

• 73040-64-9 N-[5-(2-chloro-phenyl)-thiazol-2-yl]-acetamide 
• 53-19-0 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane 
• 98557-83-6 1-o-Chlorphenyl-1-chloro-2,2-dichlorethan 
• 61693-89-8 C₁₄H₁₀Cl₃F 
• 73040-63-8 5-(2-chlorophenyl)thiazol-2-amine 
• 16608-69-8 1,1-Dichlor-2-(o-chlorphenyl)-2-(p-iodphenyl)ethan 

Relevant articles and documents

Expanding the scope of alcohol dehydrogenases towards bulkier substrates: Stereo- and enantiopreference for α,α-dihalogenated ketones

Alcohol dehydrogenases (ADHs) were identified as suitable enzymes for the reduction of the corresponding α,α-dihalogenated ketones, obtaining optically pure β,β-dichloro- or β,β-dibromohydrins with excellent conversions and enantiomeric excess. Among the different biocatalysts tested, ADHs from Rhodococcus ruber (ADH-A), Ralstonia sp. (RasADH), Lactobacillus brevis (LBADH), and PR2ADH proved to be the most efficient ones in terms of activity and stereoselectivity. In a further study, two racemic α-substituted ketones, namely α-bromo- α-chloro- and α-chloro-α-fluoroacetophenone were investigated to obtain one of the four possible diastereoisomers through a dynamic kinetic process. In the case of the brominated derivative, only the (1R)-enantiomer was obtained by using ADH-A, although with moderate diastereomeric excess (>99 % ee, 63 % de), whereas the fluorinated ketone exhibited a lower stereoselectivity (up to 45 % de). Bulking up: A series of β,β-dihalohydrins are obtained through alcohol dehydrogenase (ADH) catalyzed bioreduction of the synthesized α,α-dihalogenated ketones. Two racemic acetophenone derivatives are also subjected to this protocol to obtain stereoenriched alcohols through dynamic kinetic resolution (DKR).

REDUCTION OF CCl4, CHCl3, AND ArCH(OH)CCl3 BY ISOPROPANOL WITH INITIATION BY IRON, MOLYBDENUM, AND MANGANESE CARBONYLS

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