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Usage

Uses

Used in Personal Care Products:
Triclosan is used as an antimicrobial agent in personal care products such as soaps, toothpaste, and cosmetics. Its ability to inhibit the growth of bacteria and fungi helps maintain hygiene and prevent the spread of infections.
Used in Environmental Applications:
Despite its widespread use in personal care products, triclosan has been detected in water sources, raising concerns about its potential impact on the environment. As a result, its use has been banned or restricted in some countries to minimize its environmental footprint.
Used in Research and Development:
The potential health and environmental concerns associated with triclosan have spurred ongoing research and development efforts to find safer and more effective alternatives. This includes the exploration of alternative antimicrobial agents and the development of new formulations and delivery systems to enhance the safety and efficacy of existing compounds.

InChI:InChI=1/C8H7Cl3O/c9-6-4-2-1-3-5(6)7(12)8(10)11/h1-4,7-8,12H

Upstream product

• 36692-27-0 2-chlorophenylmagnesium bromide 
• 79-02-7 2,2-dichloroacetaldehyde 
• 75-09-2 dichloromethane 
• 89-98-5 2-chloro-benzaldehyde 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 24123-67-9 2,2‐dichloro‐1‐(2‐chlorophenyl)ethan‐1‐one 
• 10291-39-1 2,2,2-trichloro-1-(2-chloro-phenyl)-ethanol 

Downstream Products

• 53-19-0 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane 
• 16608-69-8 1,1-Dichlor-2-(o-chlorphenyl)-2-(p-iodphenyl)ethan 
• 61693-89-8 C₁₄H₁₀Cl₃F 
• 98557-83-6 1-o-Chlorphenyl-1-chloro-2,2-dichlorethan 
• 73040-64-9 N-[5-(2-chloro-phenyl)-thiazol-2-yl]-acetamide 
• 73040-63-8 5-(2-chlorophenyl)thiazol-2-amine 

Relevant academic research and scientific papers

Expanding the scope of alcohol dehydrogenases towards bulkier substrates: Stereo- and enantiopreference for α,α-dihalogenated ketones

Alcohol dehydrogenases (ADHs) were identified as suitable enzymes for the reduction of the corresponding α,α-dihalogenated ketones, obtaining optically pure β,β-dichloro- or β,β-dibromohydrins with excellent conversions and enantiomeric excess. Among the different biocatalysts tested, ADHs from Rhodococcus ruber (ADH-A), Ralstonia sp. (RasADH), Lactobacillus brevis (LBADH), and PR2ADH proved to be the most efficient ones in terms of activity and stereoselectivity. In a further study, two racemic α-substituted ketones, namely α-bromo- α-chloro- and α-chloro-α-fluoroacetophenone were investigated to obtain one of the four possible diastereoisomers through a dynamic kinetic process. In the case of the brominated derivative, only the (1R)-enantiomer was obtained by using ADH-A, although with moderate diastereomeric excess (>99 % ee, 63 % de), whereas the fluorinated ketone exhibited a lower stereoselectivity (up to 45 % de). Bulking up: A series of β,β-dihalohydrins are obtained through alcohol dehydrogenase (ADH) catalyzed bioreduction of the synthesized α,α-dihalogenated ketones. Two racemic acetophenone derivatives are also subjected to this protocol to obtain stereoenriched alcohols through dynamic kinetic resolution (DKR).

Laccase/TEMPO-mediated system for the thermodynamically disfavored oxidation of 2,2-dihalo-1-phenylethanol derivatives

An efficient methodology to oxidize β,β-dihalogenated secondary alcohols employing oxygen was achieved in a biphasic medium using the laccase from Trametes versicolor/TEMPO pair, providing the corresponding ketones in a clean fashion under very mild conditions. Moreover, a chemoenzymatic protocol has been applied successfully to deracemize 2,2-dichloro-1-phenylethanol combining this oxidation with an alcohol dehydrogenase-catalyzed bioreduction. the Partner Organisations 2014.