27685-92-3

Basic information

• Product Name: 4-HYDROXYTHIENO[3,2-C]PYRIDINE
• Synonyms: THIENO[3,2-C]PYRIDIN-4-OL;4-OXO-4,5-DIHYDROTHIENO[3,2-C]PYRIDINE;4-HYDROXYTHIENO[3,2-C]PYRIDINE;Thieno[3,2-c]pyridin-4(5H)-one;4,5-Dihydrothieno[3,2-c]pyridine-4-one;1. 4-Hydroxythieno[3,2-c]pyridine;4H,5H-thieno[3,2-c]pyridin-4-one;5H-thieno[3,2-c]pyridin-4-one
• CAS NO: 27685-92-3
• Molecular Formula: C₇H₅NOS
• Molecular Weight: 151.19
• Mol File: 27685-92-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 212 °C
• Boiling Point: 406.041 °C at 760 mmHg
• Flash Point: 199.367 °C
• Appearance: /
• Density: 1.355 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.634
• Storage Temp.: 2-8°C
• PKA: 12.36±0.20(Predicted)
• CAS DataBase Reference: 4-HYDROXYTHIENO[3,2-C]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXYTHIENO[3,2-C]PYRIDINE(27685-92-3)
• EPA Substance Registry System: 4-HYDROXYTHIENO[3,2-C]PYRIDINE(27685-92-3)

Safety Data

• Hazardous Substances Data: 27685-92-3(Hazardous Substances Data)

Usage

General Description

4-HYDROXYTHIENO[3,2-C]PYRIDINE is a chemical compound with a heterocyclic ring structure. It contains a thieno pyridine ring system with a hydroxyl group attached to the carbon atom at position 4. This chemical compound is commonly used in the pharmaceutical industry as a building block for the synthesis of various bioactive molecules, including drugs and agrochemicals. Its heterocyclic structure and functional groups make it suitable for a wide range of applications in medicinal chemistry and agrochemical research. Additionally, 4-HYDROXYTHIENO[3,2-C]PYRIDINE may also have other industrial uses, such as in the production of organic dyes or electronic materials.

InChI:InChI=1/C7H5NOS/c9-7-5-2-4-10-6(5)1-3-8-7/h1-4H,(H,8,9)

Upstream product

• 60249-02-7 4-oxo-4,5-dihydro-thieno[3,2-c]pyridine-6-carboxylic acid 
• 60249-04-9 4-ethoxy-thieno[3,2-c]pyridine-6-carboxylic acid 
• 27685-93-4 (E)-3-Thiophen-2-yl-acryloyl azide 
• 60248-96-6 2-azido-3-(3-formyl-thiophen-2-yl)-acrylic acid ethyl ester 
• 60249-11-8 2-azido-3-(3-diethoxymethyl-thiophen-2-yl)-acrylic acid ethyl ester 
• 60248-98-8 Ethyl 4,5-dihydro-4-oxothieno<3,2-c>pyridine-6-carboxylate 
• 60249-00-5 4-ethoxy-thieno[3,2-c]pyridine-6-carboxylic acid ethyl ester 
• 1124-65-8 3-(2-thienyl)-2-propenoic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 15690-25-2 3-(2-thienyl)acrylic acid 
• 28955-25-1 β-(2-Thiophen)-vinylisocyanat 
• 13979-15-2 ethyl (E)-3-(thiophen-2-yl)acrylate 
• 98-03-3 thiophene-2-carbaldehyde 
• 88-13-1 3-Thiophene carboxylic acid 

Downstream Products

• 27685-94-5 4-chlorothieno[3,2-c]pyridine 
• 215453-35-3 thieno[3,2-c]pyridin-4-amine 
• 444898-47-9 C₃₃H₂₅NO₈S 
• 29079-94-5 7-bromothieno[3,2-c]pyridine-4(5H)-one 
• 161823-02-5 4-Bromthieno<3,2-c>pyridin 
• 118376-65-1 2-(4-Oxo-4H-thieno[3,2-c]pyridin-5-yl)-propionic acid 
• 106261-27-2 4-(1-piperazinyl)thieno<3,2-c>pyridine 
• 106260-99-5 4-[4-(4-Thieno[3,2-c]pyridin-4-yl-piperazin-1-yl)-butyl]-thiomorpholine-3,5-dione; compound with toluene-4-sulfonic acid 
• 119924-11-7 4-(4-{3-[2-(4-Fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-piperazin-1-yl)-thieno[3,2-c]pyridine 
• 106260-94-0 α-(4-fluorophenyl)-4-(thieno<3,2-c>pyridin-4-yl)-1-piperazinebutanol 
• 119924-12-8 4-<4-(thieno<3,2-c>pyridin-4-yl)-1-piperazinyl>-1-(4-fluorophenyl)-1-butanone 
• 215453-39-7 2-(4-benzoylamino-thieno[3,2-c]pyridin-2-ylmethyl)-2-tert-butoxycarbonylamino-malonic acid diethyl ester 
• 215453-38-6 N-(2-hydroxymethyl-thieno[3,2-c]pyridin-4-yl)-benzamide 
• 215453-37-5 N-(2-formylthieno[3,2-c]pyridin-4-yI)benzamide 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS BET INHIBITORS

Novel bromodomain and extraterminal domain (BET) inhibitors and to therapeutic methods of treating conditions and diseases using these novel BET inhibitors are provided.

EZH2 Inhibitors

The present invention relates to compounds that inhibit EZH2 activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

Design and synthesis of piperazinylpyridine derivatives as novel 5-HT 1A agonists/5-HT3 antagonists for the treatment of irritable bowel syndrome (IBS)

We have prepared a series of piperazinylpyridine derivatives for the treatment of irritable bowel syndrome (IBS). These compounds, which were designed by pharmacophore analysis, bind to both serotonin subtype 1A (5-HT 1A) and subtype 3 (5-HT3) receptors. The nitrogen atom of the isoquinoline, a methoxy group and piper-azine were essential to the pharmacophore for binding to these receptors. We also synthesized furo- and thienopyridine derivatives according to structure-activity relationship analyses. Compound 17c (TZB-20810) had high affinities to these receptors and exhibited 5-HT1A agonistic activity and 5-HT3 antagonistic activity concurrently, and is a promising drug for further development in the treatment of IBS.