27693-67-0

Usage

Uses

Used in Biochemical and Molecular Biology Research:
2,3'-Imino-dibenzoic acid is used as a fluorescent probe for detecting and visualizing nucleic acids in biological samples. Its fluorescence properties upon binding to DNA make it a useful tool for studying the interactions between DNA and various ligands, as well as for investigating the structural and conformational changes in nucleic acids.
Used in Coordination Chemistry and Catalysis:
2,3'-Imino-dibenzoic acid is also used as a ligand in coordination chemistry and catalysis. Its versatility and potential applications in these scientific fields highlight its importance in advancing research and development in these areas.

InChI:InChI=1/C14H11NO4/c16-13(17)9-4-3-5-10(8-9)15-12-7-2-1-6-11(12)14(18)19/h1-8,15H,(H,16,17)(H,18,19)

Upstream product

• 16463-38-0 potassium 2-chlorobenzoate 
• 99-05-8 meta-aminobenzoic acid 
• 114918-37-5 methyl 2-<(3-carbomethoxyphenyl)amino>benzoate 
• 530-78-9 flufenamic acid 
• 4518-10-9 Methyl 3-aminobenzoate 
• 17763-70-1 methyl 2-(trifluoromethylsulfonyloxy)benzoate 
• 618-89-3 methyl 3-bromobenzoate 
• 118-91-2 ortho-chlorobenzoic acid 
• 134-20-3 2-carbomethoxyaniline 

Downstream Products

• 114918-37-5 methyl 2-<(3-carbomethoxyphenyl)amino>benzoate 
• 42946-36-1 9-oxo-9,10-dihydro-acridine-2-carboxylic acid 
• 71507-02-3 9-oxo-9,10-dihydro-1-acridinecarboxylic acid 
• 106626-55-5 Acridine-1-carboxylic acid (2-dimethylamino-ethyl)-amide 

Relevant academic research and scientific papers

Photochemical transformation of flufenamic acid by artificial sunlight in aqueous solutions

In the present article, we have studied the photochemical behavior of a common non-steroidal anti-inflammatory drug (NSAIDs) namely flufenamic acid (FLUA) in aqueous solution. The absorption spectrum of such compound shows a significant absorption beyond

Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N -phenyl-aminobenzoates and their structure-activity relationships

Aldo-keto reductase 1C3 (AKR1C3; type 5 17β-hydroxysteroid dehydrogenase) is overexpressed in castration resistant prostate cancer (CRPC) and is implicated in the intratumoral biosynthesis of testosterone and 5α-dihydrotestosterone. Selective AKR1C3 inhibitors are required because compounds should not inhibit the highly related AKR1C1 and AKR1C2 isoforms which are involved in the inactivation of 5α-dihydrotestosterone. NSAIDs, N-phenylanthranilates in particular, are potent but nonselective AKR1C3 inhibitors. Using flufenamic acid, 2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid, as lead compound, five classes of structural analogues were synthesized and evaluated for AKR1C3 inhibitory potency and selectivity. Structure-activity relationship (SAR) studies revealed that a meta-carboxylic acid group relative to the amine conferred pronounced AKR1C3 selectivity without loss of potency, while electron withdrawing groups on the phenylamino B-ring were optimal for AKR1C3 inhibition. Lead compounds did not inhibit COX-1 or COX-2 but blocked the AKR1C3 mediated production of testosterone in LNCaP-AKR1C3 cells. These compounds offer promising leads toward new therapeutics for CRPC.

2,7-Dihydro-3H-pyridazino[5,4,3-kl]acridin-3-one derivatives, novel type of cytotoxic agents active on multidrug-resistant cell lines. Synthesis and biological evaluation

We have earlier postulated that the presence of a pyridazone ring fused with an anthracenedione moiety resulted in the analog's ability to overcome multidrug resistance of tumor cells [J. Med. Chem. 1999, 42, 3494]. High cytotoxic activity of obtained ant

Synthesis and evaluation of anthranilic acid-based transthyretin amyloid fibril inhibitors

Eight small molecules were synthesized to evaluate the structure activity relationships (SAR) of N-substituted anthranilic acids. The molecules were synthesized by benzylation or arylation of methyl anthranilate. A light scattering-based amyloid fibril formation assay was used to evaluate potential inhibitors of transthyretin (TTR) amyloid fibril formation in vitro. The m-carboxyphenylated and o-trifluoromethylphenylated anthranilic acids are potent inhibitors that will be subjected to further SAR and structural analysis.

Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase

A series of quinazolinediones and azaquinazolinediones is described which possess potent inhibitory activity toward the calcium-independent phosphodiesterase enzyme (CaIPDE). In vivo testing showed that this in vitro activity translates to animal models p