27694-07-1

Basic information

• Product Name: 1-(1,3-dithian-2-yl)-2-phenylethan-1-one
• Synonyms: 1-(1,3-dithian-2-yl)-2-phenylethan-1-one
• CAS NO: 27694-07-1
• Molecular Weight: 238.375
• Mol File: 27694-07-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(1,3-dithian-2-yl)-2-phenylethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1,3-dithian-2-yl)-2-phenylethan-1-one(27694-07-1)
• EPA Substance Registry System: 1-(1,3-dithian-2-yl)-2-phenylethan-1-one(27694-07-1)

Safety Data

• Hazardous Substances Data: 27694-07-1(Hazardous Substances Data)

Upstream product

• 36049-90-8 2-lithio-1,3-dithiane 
• 103-80-0 phenylacetyl chloride 
• 505-23-7 1,3 dithiane 
• 95092-10-7 N-methoxy-N-methyl-2-phenylacetamide 

Relevant articles and documents

Chemistry around imidazopyrazine and ibuprofen: Discovery of novel fatty acid amide hydrolase (FAAH) inhibitors

Based on the imidazo-[1,2-a]-pyrazin-3-(7H)-one scaffold, a dual action prodrug has been designed for combining antioxidant and anti-inflammatory activities, possibly unmasked upon oxidation. The construction of the target-molecule requires two building blocks, namely a 2-amino-1,4-pyrazine and a 2-ketoaldehyde. Attempts to synthesize the 2-ketoaldehyde (5a) derived from ibuprofen failed, but led to the corresponding 2-ketoaldoxime (7a) which could not be condensed with the pyrazine synthons. However, a model compound, i.e. phenylglyoxal aldoxime, reacted well under microwave activation to furnish novel imidazo[1,2-a]-pyrazine-3-(7H)-imine derivatives (18a,b). These heterobicycles behave as antioxidants by inhibiting the lipid peroxidation, and one compound (18b) is endowed with a significant anti-inflammatory effect in a cellular test. Unexpectedly, all the synthetic intermediates derived from ibuprofen are good inhibitors of FAAH, the most active compound (4a) featuring the 1,3-dithian-2-yl motif.