27700-54-5

Basic information

• Product Name: 3-chlorophenylglyoxal
• Synonyms: 3-chlorophenylglyoxal
• CAS NO: 27700-54-5
• Molecular Weight: 168.579
• Mol File: 27700-54-5.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: 3-chlorophenylglyoxal(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chlorophenylglyoxal(27700-54-5)
• EPA Substance Registry System: 3-chlorophenylglyoxal(27700-54-5)

Safety Data

• Hazardous Substances Data: 27700-54-5(Hazardous Substances Data)

Upstream product

• 99-02-5 3'-Chloroacetophenone 

Downstream Products

• 1436865-94-9 4-[2-(3-chlorophenyl)-5-phenylfuran-3-yl]morpholine 
• 1554455-88-7 1-(3-chlorophenyl)-2-(pyrrolidin-1-yl)ethane-1,2-dione 
• 177288-16-3 C₈H₇ClO₃ 
• 935479-94-0 (+/-)-3,3-bis(benzyloxy)-2-(3-chlorophenyl)-2-(trimethylsilyloxy)propanenitrile 
• 72111-48-9 5-(3-chloro-phenyl)-pyrazine-2,3-dicarbonitrile 

Relevant articles and documents

Catalytic Asymmetric Darzens-Type Epoxidation of Diazoesters: Highly Enantioselective Synthesis of Trisubstituted Epoxides

Highly enantioselective Darzens-type epoxidation of diazoesters with glyoxal derivatives was accomplished using a chiral boron–Lewis acid catalyst, which facilitated asymmetric synthesis of trisubstituted α,β-epoxy esters. In the presence of a chiral oxazaborolidinium ion catalyst, the reaction proceeded in high yield (up to 99 %) with excellent enantio- and diastereoselectivity (up to >99 % ee and >20:1 dr, respectively). The synthetic potential of this method was illustrated by conversion of the products to various compounds such as epoxy γ-butyrolactone, tertiary β-hydroxy ketone and epoxy diester.

Oxidative C-C Bond Cleavage for the Synthesis of Aryl Carboxylic Acids from Aryl Alkyl Ketones

A metal-free and one-pot two-step synthesis of aryl carboxylic acids from aryl alkyl ketones has been achieved. The reactions were performed with iodine as the catalyst, DMSO and TBHP as the oxidants. Under the optimal reaction conditions, a number of aryl alkyl ketones could be converted into their corresponding aryl carboxylic acids in good to excellent yields (up to 94%).

Visible-light assisted one-pot preparation of aryl glyoxals from acetoarylones via in-situ arylacyl bromides formation: Selenium-free approach to acetoarylones oxidation

A novel visible-light (blue LEDs: hν?=?425?±?15?nm) photocatalyzed one-pot method for the synthesis of electronically diverse aryl glyoxals in good to excellent yields from acetoarylones and green regents such as air, vitamin C and dioxane dibromide has been described. In addition, an application of the current methodology has been demonstrated for the oxidation of monoamine oxidase-B inhibitors, i.e., 1-(4-((4-fluorobenzyl)oxy)phenyl)ethanone and 1-(3-((4-chlorobenzyl)oxy)phenyl)ethanone. This finding may serves as a valuable alternative to the traditional acetoarylones oxidation reactions conducted using selenium dioxide a harmful and unselective reagent known to simultaneously oxidize allylic, benzylic, [sbnd]CH3and so on.