27700-58-9Relevant academic research and scientific papers
Synthesis and radical scavenging activity of phenol-imidazole conjugates
Correia, Carla,Leite, Cláudia,Proen?a, M. Fernanda,Carvalho, M. Alice
, p. 2768 - 2772 (2014/06/09)
Novel hydroxylated benzylideneamino imidazole derivatives were synthesized and their radical scavenging activity was assessed against DPPH and hydroxyl radicals. In the DPPH assay, most of the synthesized compounds showed an IC 50 in the range
A short and facile synthesis for Heteromine A
Peinador, Carlos,Quintela, Jose Ma.,Moreira, Maria J.
, p. 8269 - 8272 (2007/10/03)
The first and efficient synthesis of the new pyrinium natural product Heteromine A, involving 5-amino-4-cyano-1-methylimidazole and N,N-dimethyldichlomethyleniminium chloride is reported.
Purines. LXIV syntheses of 9-methyl-2-azaadenine 1-oxide, its O-methyl derivative, and 1-substituted 5-azidoimidazole-4-carboxamides
Saito,Asahi,Nakajima,Fujii
, p. 2263 - 2268 (2007/10/02)
Diazotization of 5-amino-N'-methoxy-1-methylimidazole-4-carboxamidine (4a) with NaNO2, in 1 N aqueous HCl was found to give the 1-methoxy-2-azaadenine derivative 8a · HI, which produced 5-azido-1-methylimidazole-4-carbonitrile (5a) on treatment with aqueous Na2CO3. The ribosyl analogue 5b, obtained from the riboside 4b by similar diazotization, was utilized for the synthesis of 5-azido-1-β-D-ribofuranosylimidazole-4-carboxamide (9b), a novel AICA riboside analogue. On heating in HCONMe2 at 700C for 10 min, 8a · HI yielded the 1-N-oxide 7a. Several reactions to transform the functional groups in 5a were also investigated.
A UNIQUE TRANSFORMATION OF 5-AMINO-N'-METHOXYIMIDAZOLE-4-CARBOXAMIDINES BY DIAZOTIZATION: SYNTHESIS OF THE 5-AZIDO ANALOGUE OF AICA RIBOSIDE
Saito, Tohru,Asahi, Yayoi,Nakajima, Satoshi,Fujii, Tozo
, p. 329 - 332 (2007/10/02)
Diazotization of 1-substituted 5-amino-N'-methoxyimidazole-4-carboxamidines (I) was found to give the 5-azidoimidazole-4-carbonitriles II through the 1-methoxy-2-azaadenine intermediates IV.The product IIb from the riboside Ib was utilized for the synthesis of 5-azido-1-β-D-ribofuranosylimidazole-4-carboxamide (Vb), a novel AICA riboside analogue.
