2771-33-7

Upstream product

• 3588-64-5 N-phthaloylphenylalanine 
• 85-44-9 phthalic anhydride 
• 150-30-1 Phenylalanine 
• 56271-33-1 3-phenyl-2-(phthalimido)propanoyl chloride 

Downstream Products

• 140244-65-1 1,3-Bis-[1-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-ethyl]-urea 
• 140244-29-7 1-[1-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-ethyl]-3-(2-methoxy-phenyl)-urea 
• 140244-26-4 1-[1-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-ethyl]-3-p-tolyl-urea 
• 140244-27-5 1-(4-Chloro-phenyl)-3-[1-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-ethyl]-urea 
• 140244-25-3 1-[1-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-ethyl]-3-phenyl-urea 
• 140244-57-1 α-phthalimido-β-phenylpropionic acid phenylhydrazide 
• 140244-28-6 1-[1-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-ethyl]-3-(4-methoxy-phenyl)-urea 

Relevant academic research and scientific papers

The synthesis of N-acyl-2-hydroxymethyl aziridines of biological interest

A practical synthesis of the title compounds from protected amino acylazides is described. All the compounds might be considered as a novel class of dipeptide isostere precursors; they all induce lymphocyte proliferation and protein production as observed from preliminary biological tests.

SYNTHESIS AND REACTIONS OF PHTHALIMIDO ALIPHATIC ACID AZIDES

Azides (2a-d), in the base catalyzed decomposition with aromatic amines yielded the corresponding N-aryl-N'-alkyl ureas (4a-t) via Curtius rearrangement.However, the base catalyzed decomposition of 2 with phenylhydrazine took place via azido group displacement to afford phthalimido aliphatic acid phenylhydrazides (8a-d).Decomposition of azides (2a-d) in neutral medium yielded the corresponding sym-N,N'-di-alkyl ureas (9a-d), via Curtius rearrangement.