3588-64-5Relevant articles and documents
Synthesis of 2-amino-1-indanone from DL-phenylalanine
Zhao, Rong,Guo, Peijiang,Dong, Junyu,Zhang, Xiaoping,Sun, Xiaofei,Tian, Yun,Zeng, Qingle
, p. 377 - 380 (2011)
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NOVEL TRF1 MODULATORS AND ANALOGUES THEREOF
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Paragraph 0047; 0064-0065; 0156-0157, (2020/03/26)
Novel TRF1 modulators and analogues thereof. There is provided compounds of Formula I, wherein R, R1, R2 and X have meanings written in the description. Such compounds are useful as TRF1 inhibitors and, for that reason, as medicaments, in the treatment of cancer, particularly high cancer stem cell cancer like glioblastoma and lung cancer, and can be also useful for the development of additional TRF1 inhibitors and increasing knowledge about TRF1 activity.
A Novel Class of 7-Membered Heterocyclic Compounds
Bauer, Adriano,Borsos, Eszter,Maulide, Nuno
supporting information, p. 3971 - 3974 (2020/05/25)
The work presented herein describes the synthesis of a formerly inaccessible class of heterocyclic compounds. The reaction relies on α-phthalimido-amides, which are readily prepared from amino acids in 2 simple reactions steps. Under amide activation conditions in which classical keteniminium ions are not formed, the nitrile solvent is incorporated into the new fused 7-membered ring system. Due to the absence of a keteniminium intermediate, the stereogenic information in the α-position is fully retained.
