2771-55-3Relevant articles and documents
Immobilization of UDP-Galactose on an Amphiphilic Resin
Bevan, Jessica G. M.,Louren?o, Eva C.,Chaves-Ferreira, Miguel,Rodrigues, Jo?o A.,Rita Ventura
supporting information, p. 908 - 914 (2018/02/27)
Nucleotide sugars are activated sugar precursors used by glycosyltransferases to form glycans. Here we report the first examples of resin-bound nucleotide sugars: fluorinated UDP-galactose and UDP-galactose. They were conjugated to a polyethylene glycol resin through the C6 position with an SMCC linker in good to excellent yields. This synthesis represents an efficient method to access resin-bound nucleotide sugars in a modular approach that enables modifications of the sugar or nucleotide before conjugation. The system has been conceived as a new chemistry-based screening system for enzymes that use UDP-galactose.
Impact of sugar stereochemistry on natural killer T cell stimulation by bacterial glycolipids
Deng, Shenglou,Mattner, Jochen,Zang, Zhuo,Bai, Li,Teyton, Luc,Bendelac, Albert,Savage, Paul B.
supporting information; experimental part, p. 7659 - 7662 (2011/12/04)
Natural killer T (NKT) cells recognize glycolipids produced by Sphingomonas bacteria, and these glycolipids contain C6-oxidized sugars, either glucuronic acid or galacturonic acid, linked to ceramides. Glycolipids with gluco stereochemistry are the most p
Divergent synthesis of L-sugars and L-iminosugars from D-sugars
Takahashi, Hideyo,Shida, Tomomi,Hitomi, Yuko,Iwai, Yoshinori,Miyama, Namisa,Nishiyama, Kazusa,Sawada, Daisuke,Ikegami, Shiro
, p. 5868 - 5877 (2008/03/11)
An efficient divergent synthesis of L-sugars and L-iminosugars from D-sugars is described. The important intermediate. δ-hydroxyalkoxamate. prepared from D-glucono-/galactono-1,5-lactone, was cyclized under Mitsunobu conditions to give the O-cyclized oxim