277300-08-0

Upstream product

• 67-56-1 methanol 
• 143-33-9 sodium cyanide 
• 101563-66-0 6-phenyl-5-hydroxymethyl-2H-pyridazin-3-one 
• 101563-68-2 6-oxo-3-phenyl-1,6-dihydropyridazine-4-carbaldehyde 
• 252920-10-8 5-methoxycarbonyl-6-phenyl-3(2H)-pyridazinone 
• 442123-62-8 4-cyano-5-(1'-cyanohydroxymethyl)-6-phenyl-3(2H)-pyridazinone 

Relevant academic research and scientific papers

Pyridazines. Part 22: Highly efficient synthesis of pharmacologically useful 4-cyano-6-phenyl-5-substituted-3(2H)-pyridazinones

A cyano group was directly and efficiently attached at the 4-position of the heterocyclic ring of 5-substituted-6-phenyl-3(2H)-pyridazinones using a practical and mild procedure. This direct cyanide addition offers a novel and one-pot approach to the synthesis of pharmacologically useful 4,5- difunctionalized-6-phenyl-3(2H)-pyridazinones. (C) 2000 Elsevier Science Ltd.

Pyridazine derivatives. Part 27: A joint theoretical and experimental approach to the synthesis of 6-phenyl-4,5-disubstituted-3(2H)-pyridazinones

A theoretical study of the structures of a series of 5-substituted-6-phenyl-3(2H)-pyridazinones has been carried out using quantum-mechanical calculations. This study indicates a significant effect of the nature of the substituent at the 5-position on the

Pyridazines. Part 31: synthesis and antiplatelet activity of 4,5-disubstituted-6-phenyl-3(2H)-pyridazinones.

This paper describes the synthesis and the antiplatelet activity of a series of 4,5-disubstituted-6-phenyl-3(2H)-pyridazinones. Some of these compounds show a dose-dependent activity and were found to be more active than their 5-substituted analogues.