2775-88-4Relevant academic research and scientific papers
CHARACTERISATION OF ADDUCTS OF NUCLEIC BASES AND ACRYLIC MONOMERS
Crippa, Sergio,Di Gennaro, Patrizia,Lucini, Ruggero,Orlandi, Marco,Rindone, Bruno
, p. 197 - 203 (2007/10/02)
Spectral data and thermodynamic calculations of adducts of purines (guanine, adenine), or pyrimidines (thymine, uracil) with acrylic monomers (acrylonitrile, ethyl acrylate, and ethyl crotonate) are reported.Purine adducts derive from attack at N-7 and N-9, and pyrimidine adducts derive from attack at N-1.Acrylonitrile forms also N-1, N-3 bis adducts with pyrimidines.Structural assignment was by 1H and 13C NMR and using COSY-RELAY and NOE effects.Force-field calculations indicated the most stable conformations of the reaction products.
