278179-04-7Relevant articles and documents
Anilides of (R)-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase
Bebernitz, Gregory R.,Aicher, Thomas D.,Stanton, James L.,Gao, Jiaping,Shetty, Suraj S.,Knorr, Douglas C.,Strohschein, Robert J.,Tan, Jennifer,Brand, Leonard J.,Liu, Charles,Wang, Wei H.,Vinluan, Christine C.,Kaplan, Emma L.,Dragland, Carol J.,DelGrande, Dominick,Islam, Amin,Lozito, Robert J.,Liu, Xilin,Maniara, Wieslawa M.,Mann, William R.
, p. 2248 - 2257 (2000)
The optimization of a series of anilide derivatives of (R)-3,3,3- trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase (PDHK) is described that started from N-phenyl-3,3,3- trifluoro-2-hydroxy-2-methylpropanamide 1 (IC
