278183-73-6Relevant academic research and scientific papers
Optimization of imidazole 5-lipoxygenase inhibitors and selection and synthesis of a development candidate
Mano, Takashi,Stevens, Rodney W.,Ando, Kazuo,Kawai, Makoto,Kawamura, Kiyoshi,Nakao, Kazunari,Okumura, Yoshiyuki,Okumura, Takako,Sakakibara, Minoru,Miyamoto, Kimitaka,Tamura, Tetsuya
, p. 965 - 973 (2007/10/03)
Structural modification of imidazole 5-lipoxygenase (5-LO) inhibitors for optimizing inhibitory potency, pharmacokinetic behavior and toxicity (ocular) profile led to 4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]}phenyl-3,4,5,6- tetrahydro-2H-pyran-4-car
5-Lipoxygenase inhibitors: Convenient synthesis of 4-[3-(4- heterocyclylphenylthio)phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide analogues
Mano, Takashi,Stevens, Rodney W.,Okumura, Yoshiyuki,Kawai, Makoto,Okumura, Takako,Sakakibara, Minoru
, p. 2611 - 2615 (2007/10/03)
A convenient synthetic route to 4-[3-(4-heterocyclylphenylthio)phenyl]-3,4, 5,6-tetrahydro-2H-pyran-4-carboxamide analogues as 5-LO inhibitors is described. This methodology enabled rapid development of structure-activity relationships (SARs) leading to i
Process for preparing 5-lipoxygenase inhibitors
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, (2008/06/13)
The present invention relates to the process for preparing a compound of the formula wherein A is C1-C6alkyl, an aryl which is mono or disubstituted with F, Cl, Br, OCH3, C1-C3alkyl or benzy. In the p
