179420-75-8

Usage

Uses

Used in Medicinal Chemistry:
1-(4-Iodo-phenyl)-2-methyl-1H-imidazole is used as a building block for the development of pharmaceutical drugs due to its potential pharmacological properties.
Used in Organic Synthesis:
1-(4-Iodo-phenyl)-2-methyl-1H-imidazole is also utilized in organic synthesis, serving as a key intermediate for the creation of various organic compounds.
Used in Chemical Research and Development:
1-(4-Iodo-phenyl)-2-methyl-1H-imidazole may be employed in the field of chemical research and development for exploring its properties and applications further.

Upstream product

• 693-98-1 2-methylimidazole 
• 352-34-1 4-fluoro-1-iodobenzene 

Downstream Products

• 278183-73-6 4-cyano-4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]}phenyl-3,4,5,6-tetrahydro-2H-pyran 
• 189277-92-7 (1S,3R,5R)-3-{3-[4-(2-Methyl-imidazol-1-yl)-phenylsulfanyl]-phenyl}-8-oxa-bicyclo[3.2.1]octane-3-carbonitrile 
• 179420-53-2 ethyl 4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]phenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate 
• 179420-34-9 4-cyano-4-{5-fluoro-3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]phenyl}-3,4,5,6-tetrahydro-2H-pyran 
• 179420-54-3 4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]phenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylic acid 
• 179420-35-0 4-{5-fluoro-3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]phenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide 
• 179420-17-8 4-[3-[4-(2-methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide 

Relevant academic research and scientific papers

Optimization of imidazole 5-lipoxygenase inhibitors and selection and synthesis of a development candidate

Structural modification of imidazole 5-lipoxygenase (5-LO) inhibitors for optimizing inhibitory potency, pharmacokinetic behavior and toxicity (ocular) profile led to 4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]}phenyl-3,4,5,6- tetrahydro-2H-pyran-4-car

Imidazole lipoxygenase inhibitors

PCT No. PCT/IB96/00744 Sec. 371 Date Jun. 29, 1998 Sec. 102(e) Date Jun. 29, 1998 PCT Filed Jul. 24, 1996 PCT Pub. No. WO97/11079 PCT Pub. Date Mar. 27, 1997The present invention provides a compound of formula (I): and a pharmaceutically acceptable salt thereof, wherein Ar is phenylene optionally substituted with halo, hydroxy, cyano, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 halo-substituted alkyl or C1-C4 halo-substituted alkoxy, X is -A-X1- or -X2-A-, where A is a direct bond or C1-C4 alkylene, and X1 is oxy, thio, sulfinyl or sulfonyl; Ar is phenylene, pyridylene or thienylene optionally substituted with halo, hydroxy, cyano, nitro, amino, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 halo-substituted alkyl, C1-C4 halo-substituted alkoxy, C1-C4 alkylamino or di(C1-C4)alkylamino; Y is CN or CONR1R2 wherein R1 and R2 are independently hydrogen or C1-C4 alkyl; and R is hydrogen or C1-C6 alkyl; W is C2-C3 alkylene, one carbon atom of which may be replaced by an oxygen atom. Further the invention provides a pharmaceutical composition for treating an inflammatory disease, allergy or cardiovascular diseases or the like in a mammalian subject which comprises a compound of formula (I) and a pharmaceutically acceptable carrier.

5-lipoxygenase inhibitors

Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: STR1 and the pharmaceutically acceptable salts thereof, wherein Ar1 is a heterocyclic moiety which is selected from imidazolyl, pyrrolyl, py