27822-68-0

Usage

Uses

Used in Paint Industry:
1-(2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone is used as a solubilizer and coupling agent for enhancing the solubility and stability of various components in paint formulations.
Used in Ink Industry:
In the ink industry, 1-(2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone serves as a solubilizer and wetting agent, improving the flow and dispersion of ink on different surfaces.
Used in Adhesive Industry:
As a component in adhesive formulations, 1-(2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone acts as a solubilizer and coupling agent, promoting better adhesion and compatibility with various substrates.
Used in Polymer Industry:
In polymer applications, 1-(2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone is utilized as a solubilizer and wetting agent, contributing to the improved processability and performance of polymer materials.
Used in Organic Synthesis:
1-(2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone is employed as a reaction medium in organic synthesis due to its high boiling point and low vapor pressure, making it an ideal solvent for a variety of chemical reactions.

Upstream product

• 108-24-7 acetic anhydride 
• 498-63-5 2-hydroxymethylpyrrolidine 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 

Downstream Products

• 133129-46-1 (R)-N-((R)-1-Ethyl-pyrrolidin-2-ylmethyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 
• 133129-46-1 (R)-N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 
• 26116-12-1 1-ethyl-2-pyrrolidinemethanamine 
• 73323-64-5 1-acetyl-2-formylpyrrolidine 
• 54385-06-7 1-acetyl-2-chloromethyl-pyrrolidine 

Relevant academic research and scientific papers

Additive-free chemoselective acylation of amines

Aliphatic and aromatic amines are efficiently acylated by acetic, pivalic, benzoic, phthalic, or maleic anhydrides in ethyl acetate at room temperature. Under the same experimental conditions, amino alcohols are chemoselectively acylated at the amino group.

Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: High-affinity ligands for CNS dopamine D2 receptors

A number of 2,3-dimethoxy-5-(fluoroalkyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl] benzamides (with or without a 6-hydroxy group) were synthesized and evaluated as dopamine D2 receptor ligands. The parent acids were synthesized via the Claisen rearrangement of the appropriate O-allyl ethers, which were derived from o-vanillic acid or 2,3-dimethoxysalicylic acid. A decrease in reactivity was found to be characteristic of pentasubstituted benzoates, and difficulties were encountered with the introduction of fluorine onto the ethyl side chains. The (fluoroethyl)- and (fluoropropyl)salicylamides were 5 times more potent than the corresponding benzamides in inhibiting [3H]spiperone binding to the D2 receptor. These (fluoroalkyl)salicylamides are of potential value for in vivo positron emission tomography (PET) studies upon the basis of their relatively selective, high potency binding affinity for the D2 receptor.

Synthesis of Analogues of 1,3-Dihydroxyacetone Phosphate and Glyceraldehyde 3-Phosphate for Use in Studies of Fructose-1,6-diphosphate Aldolase

This paper describes the synthesis of five analogues of dihydroxyacetone phosphate (3-azidohydroxyacetone 1-phosphate (5), 3-(acetylamino)hydroxyacetone 1-phosphate (12), (R)-1,3-dihydroxy-2-butanone 1-phosphate (18), (+/-)-1,3-dihydroxy-2-butanone 3-phosphate (26), and phosphonomethyl glycolate (31)).The syntheses of 18 and 26 are based on a new reaction: that is, the introduction of the phosphate group by the reaction of a diazo ketone with dibenzyl phosphate.These methods provide easy access to a number of compounds that are potential substrates for the synthetically useful enzyme aldolase (fructose-1,6-diphosphate aldolase from rabbit muscle, EC 4.1.2.13, RAMA) and perhaps for other enzymes of glycolysis.This paper also describes syntheses of 14 aldehydes for examination as substrates for aldolase.When the precursor was available, ozonolysis of vinyl groups proved to be the best route to the corresponding aldehydes.