27827-33-4

Upstream product

• 4056-56-8 N-(phenylsulfonyl)-1,4-benzoquinone monoimine 
• 135-19-3 β-naphthol 
• 1075749-15-3 C₃₂H₃₃NO₈S 

Downstream Products

• 114855-70-8 N-phenylsulfonyl-2-(2-acetoxy-1,2-dihydro-1-oxo-2-naphthyl)-1,4-naphthoquinone 4-imine 
• 38045-22-6 2-(2-hydroxy-1-naphthyl)-4-aminophenol 
• 31536-11-5 N-phenylsulfonyl-2-(2-hydroxy-1-naphthyl)-1,4-benzoquinone 4-imine 

Relevant academic research and scientific papers

Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: Heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay

Heat shock protein 90 is emerging as an important target in cancer chemotherapy. In a program directed toward identifying novel chemical probes for Hsp90, we found N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)benzene sulfonamide as an Hsp90 inhibitor with very weak activity. In this report, we present a new and general method for the synthesis of a variety of analogs around this scaffold, and discuss their structure-activity relationships.

STRUCTURE OF PRODUCTS FROM THE REACTION OF N-ARYLSULFONYL-p-QUINONE IMINES WITH NAPHTHOLS

Evidence was obtained for the addition of 2-naphthols to N-arylsulfonyl-p-benzo(naphtho)quinone imines at position 1 and of 1-naphthols at position 2 with the formation of 2-hydroxyaryl-4-arylsulfonylaminophenols (or the corresponding 1-naphthols). 5-Phen