2784-27-2Relevant articles and documents
Stable-isotope methodology for the bioavailability study of phenytoin during multiple-dosing regimens
Kasuya,Mamada,Baba,Matsukura
, p. 503 - 507 (1985)
With the highly sensitive and specific gas chromatography-mass spectrometry (GC-MS), plasma concentrations resulting from an intravenous administration of only a small amount of stable isotopically labeled phenytoin (DPH-d10) were determined to obtain information on the accurate clearance values under steady-state conditions attained with unlabeled phenytoin (DPH-d0). A time course of DPH-d10 concentrations was followed simultaneously with DPH-d0 during dosing intervals by GC-MS, with DPH-d5 as an internal standard. The present stable-isotope methodology offered advantages for the estimation of absolute bioavailability of the oral phenytoin dose in patients, while normal therapy was continued and not withdrawn.
Deracemization of 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH): Practical synthesis of (-)-(S)-HPPH
Riedner, Jens,Vogel, Pierre
, p. 2657 - 2660 (2007/10/03)
In the presence of 10% NaOH in boiling MeOH enantiomerically enriched HPPH is racemized. This permits the deracemization of HPPH in the presence of brucine, giving enantiomerically pure (-)-(S)-HPPH [(-)-(S)-5-(4-hydroxyphenyl)- 5-phenylhydandoin].
Comparative study on the para-metabolic oxidation of phenytoin and decadeuteriophenytoin
Moustafa,El-Emam,Subbagh,Sharaf El-Din
, p. 1076 - 1078 (2007/10/02)
The in-vivo metabolic conversion of equal mixture of phenytoin and decadeuteriophenytoin to the para-hydroxy metabolite in rat was investigated in order to verify a possible role of an insertion or abstraction mechanisms in the hydroxylation process. Determination of k(H)/k2(H) values of urine samples at 2 h intervals for 24 h indicated that there was no isotope effect during in-vivo para-hydroxylation of phenytoin. This gives evidence of the arene oxide intermediacy possibly being the sole pathway for para-hydroxylation of phenytoin.