27845-66-5Relevant academic research and scientific papers
1,3-Difunctionalization of Aminocyclopropanes via Dielectrophilic Intermediates
Wang, Ming-Ming,Waser, Jér?me
, p. 13880 - 13884 (2019)
We report an oxidative ring-opening strategy to transform acyl, sulfonyl or carbamate protected aminocyclopropanes into 1,3-dielectrophilic carbon intermediates bearing a halide atom (Br, I) and a N,O-acetal. Replacing the alkoxy group of the N,O-acetal can be achieved under acidic conditions through an elimination–addition pathway, while substitution of the halides by nucleophiles can be done under basic conditions through a SN2 pathway, generating a wide range of 1,3-difunctionalized propylamines. A proof of concept for asymmetric induction was realized using a chiral phosphoric acid (CPA) as catalyst, highlighting the potential of the method in enantioselective synthesis of important building blocks.
A cinnamide derivatives and use thereof
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Paragraph 0030-0033, (2019/07/04)
The invention discloses a cinnamide derivatives, its structure is shown as formula I: In the general formula (I): R selected from cyclopropyl, cyclobutyl, cyclopropyl methyl, allyl, trifluoroethyl or 2 - fluorophenyl. The invention also disclosed the abov
NHC-catalyzed C-O or C-N bond formation: Efficient approaches to α,β-unsaturated esters and amides
Zhang, Bo,Feng, Peng,Cui, Yuxin,Jiao, Ning
supporting information; experimental part, p. 7280 - 7282 (2012/07/28)
Simple and efficient NHC-catalyzed transformations of bromoenal or α,β-dibromoenal into α,β-unsaturated esters or amides with high stereoselectivity through C-O or C-N bond formation have been demonstrated. The NHC-catalyzed processes occur under mild con
