27845-77-8Relevant academic research and scientific papers
Isoquinoline-based chiral monodentate N-heterocyclic carbenes
Hirsch-Weil, Dimitri,Abboud, Khalil A.,Hong, Sukwon
supporting information; experimental part, p. 7525 - 7527 (2010/12/18)
C1-symmetric isoquinoline-based chiral diaminocarbene ligands (MIQ) have been developed to block three quadrants of the metal coordination sphere, complementing C2-symmetric biisoquinoline-based ligands (BIQ). MIQ-Cu complexes catalyzed conjugate borylation of various α,β-unsaturated amides in good yields (82-99%) and enantioselectivities (75-87% ee).
Synthesis of α,β-unsaturated amides by olefin cross-metathesis
Choi, Tae-Lim,Chatterjee, Arnab K.,Grubbs, Robert H.
, p. 1277 - 1279 (2007/10/03)
Electronic and steric properties of the substituents on the amide nitrogen atom govern the yield and rate of the cross-metathesis between a variety of αβ-unsaturated amides and olefins with 1 as the catalyst. This influence is the result of deactivation of the catalyst by chelation of the carbonyl group to the metal. However, an increase in catalyst loading compensates for the chelation effect.
