Tetrahedron p. 6567 - 6576 (1999)
Update date:2022-09-26
Topics:
Appendino, Giovanni
Belloro, Emanuela
Jakupovic, Sven
Danieli, Bruno
Jakupovic, Jasmin
Bombardelli, Ezio
Starting from taxanes available in multigram amounts from widespread ornamental yews (10-deacetylbaccatin III (4) and 2'-deacetoxyaustrospicatine (5)), two dimeric taxoids (3a, 3b) with potential dual target specificity (β-tubulin and P-gp) were synthesised. Both compounds lacked significant cytotoxicity, though 3b retained a strong activity in the tubulin depolimerisation assay.
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