Tetrahedron p. 6567 - 6576 (1999)
Update date:2022-09-26
Topics:
Appendino, Giovanni
Belloro, Emanuela
Jakupovic, Sven
Danieli, Bruno
Jakupovic, Jasmin
Bombardelli, Ezio
Starting from taxanes available in multigram amounts from widespread ornamental yews (10-deacetylbaccatin III (4) and 2'-deacetoxyaustrospicatine (5)), two dimeric taxoids (3a, 3b) with potential dual target specificity (β-tubulin and P-gp) were synthesised. Both compounds lacked significant cytotoxicity, though 3b retained a strong activity in the tubulin depolimerisation assay.
View MoreContact:+86-27-85733560
Address:NO.308,QINGNIAN RD.,WUHAN,CHINA
Shandong General Materials Co.,Ltd（Shandong Aoertong Chemical Co., Ltd）
Contact:86-531-88072280
Address:No. 1825 Hualong Road, Licheng District, Jinan, Shandong, China
Zhangjiagang Golden Reach Fine Chemical Co.,LTD.
Contact:+86-512-6585 6968
Address:Changfu Road， Dongsha Chemical Industry Park, Zhangjiagang City, Jiangsu Province, China
Sanming Coffer Fine Chemical Industrial Co., Ltd
website:http://www.cofferxm.com/
Contact:+86-598-5853979
Address:Jin-sha Yuan Chuang-ye Park,Hi-Tech Development Zone,Sanming City P.R.China
Nanjing Raise Pharmatech Co., Ltd
website:http://www.raisechem.com
Contact:+86-25-58649566
Address:B381,No.606,Ningliu Road,Jiangbei New Area,Nanjing,Jiangsu Province,China
Doi:10.1021/ja00966a026
(1966)Doi:10.1021/jo00808a010
(1971)Doi:10.1016/S0040-4039(01)88738-4
(1969)Doi:10.1039/b000196l
(2000)Doi:10.1007/BF00771800
()Doi:10.1016/j.jfluchem.2004.09.002
(2004)
