278597-32-3

Basic information

• Product Name: 2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]-benzaldehyde
• Synonyms: 2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]-benzaldehyde;Benzaldehyde, 2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-Methylethyl)-4-isoxazolyl]Methoxy]-;2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)Methoxy)benzaldehyde;3-(2,6-dichlorophenyl)-4-(3'-chloro-4'-forMylphenoxy)-Methyl-5-isopropyl-isoxazole
• CAS NO: 278597-32-3
• Molecular Formula: C₂₀H₁₆Cl₃NO₃
• Molecular Weight: 424.70494
• Mol File: 278597-32-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 551.792°C at 760 mmHg
• Flash Point: 287.514°C
• Appearance: /
• Density: 1.357g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: 2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]-benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]-benzaldehyde(278597-32-3)
• EPA Substance Registry System: 2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]-benzaldehyde(278597-32-3)

Safety Data

• Hazardous Substances Data: 278597-32-3(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]-benzaldehyde is a chemical compound with a complex structure. It contains a benzaldehyde group attached to a chlorine atom, a 2,6-dichlorophenyl group, and a 4-isoxazolyl group with an isopropyl substituent. The compound also features a methoxy group connected to the isoxazolyl moiety. This chemical may have potential applications in pharmaceuticals, agrochemicals, or materials science due to its unique structure and functional groups. Its properties and potential uses would require further study and investigation.

InChI:InChI=1/C20H16Cl3NO3/c1-11(2)20-14(10-26-13-7-6-12(9-25)17(23)8-13)19(24-27-20)18-15(21)4-3-5-16(18)22/h3-9,11H,10H2,1-2H3

Upstream product

• 56962-11-9 2-chloro-4-hydroxybenzaldehyde 
• 278597-30-1 [3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methanol 
• 6579-27-7 2,6-dichlorobenzohydroximoyl chloride 
• 700835-81-0 4-(chloromethyl)-3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole 
• 278597-28-7 methyl 3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole-4-carboxylate 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 25185-95-9 2,6-dichlorobenzaldoxime 

Downstream Products

• 1573119-82-0 3-(2,6-dichlorophenyl)-4-(2'-methoxycarbonyl-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole 
• 1573119-78-4 3-(2,6-dichlorophenyl)-4-(2'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole 
• 1573119-80-8 3-(2,6-dichlorophenyl)-4-(4'-methoxycarbonyl-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole 
• 1374961-95-1 2-{N-benzyl-2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzamido}benzoic acid 
• 1374961-87-1 methyl 4-{N-benzyl-2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzamido}benzoate 
• 1374961-86-0 methyl 2-{N-benzyl-2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzamido}benzoate 
• 1374961-91-7 methyl 4-{[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-yl]methoxy]benzoyl]amino}benzoate 
• 1374961-90-6 methyl 2-{2-chloro-4-[(3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy]benzamido}benzoate 
• 1374961-71-3 3-{2-chloro-{4-[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-N-[2-naphtylmethyl]benzamido}benzoic acid 
• 1374961-70-2 3-{2-chloro-{4-[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-N-[1-naphtylmethyl]benzamido}benzoic acid 
• 1374961-69-9 3-{2-chloro-{4-[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-N-butylbenzamido}benzoic acid 
• 1374961-68-8 methyl 3-{N-(2-naphtylmethyl)-2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzamido}benzoate 
• 1374961-67-7 methyl 3-{N-(1-naphtylmethyl)-2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzamido}benzoate 
• 1374961-66-6 methyl 3-{N-(1-butyl)-2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzamido}benzoate 

Relevant articles and documents

Design and Structural Optimization of Dual FXR/PPARδActivators

Nonalcoholic steatohepatitis (NASH) is considered as severe hepatic manifestation of the metabolic syndrome and has alarming global prevalence. The ligand-activated transcription factors farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR) δhave been validated as molecular targets to counter NASH. To achieve robust therapeutic efficacy in this multifactorial pathology, combined peripheral PPAR?-mediated activity and hepatic effects of FXR activation appear as a promising multitarget approach. We have designed a minimal dual FXR/PPARδactivator scaffold by rational fusion of pharmacophores derived from selective agonists. Our dual agonist lead compound exhibited weak agonism on FXR and PPARδand was structurally refined to a potent and balanced FXR/PPARδactivator in a computer-aided fashion. The resulting dual FXR/PPARδmodulator comprises high selectivity over related nuclear receptors and activates the two target transcription factors in native cellular settings.

FARNESOID X RECEPTOR AGONISTS

The invention relates to a compound of formula (I) useful as an agonist for FXR: wherein all variables are as defined herein and to pharmaceutical compositions, methods of using, and processes for preparing the same.

Identification of a chemical tool for the orphan nuclear receptor FXR

-