278611-17-9Relevant academic research and scientific papers
An alternative synthesis of HPMPC and HPMPA diphosphoryl derivatives
Otmar, Miroslav,Masojidkova, Milena,Votruba, Ivan,Holy, Antonin
, p. 500 - 506 (2001)
In (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC) and (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA) with 3-hydroxy functions protected with 4,4′-dimethoxytrityl (DMTr) groups, phosphonate groups were transformed to the morpholides and treated with bis(tributylammonium) diphosphate. Selective cleavage of the DMTr group in the presence of the labile diphosphate residue was achieved in water at pH 2.5. Purification by charcoal adsorption followed by anion exchange chromatography afforded phosphonate-diphosphate compounds (HPMPCpp, HPMPApp).
Substituted Phosphate Esters of Nucleoside Phosphonates
-
Page/Page column 31-32, (2009/07/03)
Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections and/or cell proliferation. The compounds provided herein are obtained by attaching the phosphonate nucleo
