278611-19-1

Basic information

• Product Name: (S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine trisodium salt
• CAS NO: 278611-19-1
• Molecular Weight: 741.522
• Mol File: 278611-19-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine trisodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine trisodium salt(278611-19-1)
• EPA Substance Registry System: (S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine trisodium salt(278611-19-1)

Safety Data

• Hazardous Substances Data: 278611-19-1(Hazardous Substances Data)

Upstream product

• 278611-17-9 (S)-1-{3-[4,4'-Dimethoxytrityloxy]-2-(phosphonomethoxy)propyl}cytosine 
• 278611-18-0 {1-(4-amino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxymethyl}-morpholin-4-yl-phosphinic acid 
• 113852-37-2 cidofovir 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Relevant articles and documents

An alternative synthesis of HPMPC and HPMPA diphosphoryl derivatives

In (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC) and (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA) with 3-hydroxy functions protected with 4,4′-dimethoxytrityl (DMTr) groups, phosphonate groups were transformed to the morpholides and treated with bis(tributylammonium) diphosphate. Selective cleavage of the DMTr group in the presence of the labile diphosphate residue was achieved in water at pH 2.5. Purification by charcoal adsorption followed by anion exchange chromatography afforded phosphonate-diphosphate compounds (HPMPCpp, HPMPApp).