278618-79-4

Upstream product

• 518-28-5 podofilox 
• 6559-91-7 4'-demethylepipodophyllotoxin 
• 290371-79-8 (5S,5aR,8aR,9R)-9-(4-Hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carbonitrile 

Downstream Products

• 1252007-76-3 C₂₉H₃₄N₂O₈ 
• 1252007-73-0 C₂₈H₃₂N₂O₉ 
• 1252007-79-6 C₃₄H₃₆N₂O₈ 
• 1252007-63-8 C₃₂H₃₂N₂O₉ 
• 1252007-82-1 C₃₄H₃₅NO₈ 
• 327082-16-6 C₃₀H₂₉NO₈ 
• 1252007-80-9 C₃₀H₃₀N₂O₈ 
• 1252007-81-0 C₂₆H₃₀N₂O₈ 

Relevant academic research and scientific papers

Design and synthesis of novel cytotoxic podophyllotoxin derivatives

In order to investigate the effect of different C4 linkage moieties on the cytotoxicity of podophyllotoxin derivatives, novel 4-N- and 4-C-substituted 4'-O-demethylepipodophyllotoxin derivatives were designed and synthesized. All the compounds were tested against A549 and MCF-7 tumor cells in vitro, and six compounds showed significant cytotoxicity. The most active compound 9f was superior to GL-331, and exhibited potent cytotoxicity with IC50 value at 10-7mol/L level.

Antitumor agents. Part 227: Studies on novel 4′-O-demethyl- epipodophyllotoxins as antitumor agents targeting topoisomerase II

Eight novel epipodophyllotoxin derivatives (6-13), which were designed to overcome drug resistance and enhance topoisomerase II inhibition, were synthesized and evaluated. Two of these compounds (7 and 8) showed better preclinical activity profiles, inclu