290371-79-8

Upstream product

• 6559-91-7 4'-demethylepipodophyllotoxin 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 278618-79-4 (5S,5aS,8aR,9R)-9-(4-Hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carboxylic acid 
• 327082-16-6 C₃₀H₂₉NO₈ 
• 1252007-82-1 C₃₄H₃₅NO₈ 
• 1252007-81-0 C₂₆H₃₀N₂O₈ 
• 1252007-80-9 C₃₀H₃₀N₂O₈ 
• 1252007-79-6 C₃₄H₃₆N₂O₈ 
• 1252007-76-3 C₂₉H₃₄N₂O₈ 
• 1252007-73-0 C₂₈H₃₂N₂O₉ 
• 1252007-63-8 C₃₂H₃₂N₂O₉ 

Relevant academic research and scientific papers

Design and synthesis of novel cytotoxic podophyllotoxin derivatives

In order to investigate the effect of different C4 linkage moieties on the cytotoxicity of podophyllotoxin derivatives, novel 4-N- and 4-C-substituted 4'-O-demethylepipodophyllotoxin derivatives were designed and synthesized. All the compounds were tested against A549 and MCF-7 tumor cells in vitro, and six compounds showed significant cytotoxicity. The most active compound 9f was superior to GL-331, and exhibited potent cytotoxicity with IC50 value at 10-7mol/L level.

Antitumor agents. Part 227: Studies on novel 4′-O-demethyl- epipodophyllotoxins as antitumor agents targeting topoisomerase II

Eight novel epipodophyllotoxin derivatives (6-13), which were designed to overcome drug resistance and enhance topoisomerase II inhibition, were synthesized and evaluated. Two of these compounds (7 and 8) showed better preclinical activity profiles, inclu