279227-10-0

Basic information

• Product Name: Undecanoic acid, 3,7-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,4,6,8-tetramethyl-5-oxo-1 1-(phenylmethoxy)-, methyl ester, (3S,6R,7S,8S)-
• CAS NO: 279227-10-0
• Molecular Formula: C35H64O6Si2
• Molecular Weight: 637.061
• Mol File: 279227-10-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Undecanoic acid, 3,7-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,4,6,8-tetramethyl-5-oxo-1 1-(phenylmethoxy)-, methyl ester, (3S,6R,7S,8S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Undecanoic acid, 3,7-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,4,6,8-tetramethyl-5-oxo-1 1-(phenylmethoxy)-, methyl ester, (3S,6R,7S,8S)-(279227-10-0)
• EPA Substance Registry System: Undecanoic acid, 3,7-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,4,6,8-tetramethyl-5-oxo-1 1-(phenylmethoxy)-, methyl ester, (3S,6R,7S,8S)-(279227-10-0)

Safety Data

• Hazardous Substances Data: 279227-10-0(Hazardous Substances Data)

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 250679-51-7 (3S)-1-[(1S,5R)-10,10-dimethyl-3,3-dioxido-3-thia-4-azatricyclo[5.2.1.0^1.5]dec-4-yl]-3-hydroxy-4,4-dimethylheptan-1,5-dione 
• 250679-54-0 (4S)-4-benzyl-3-[(2S)-5-(benzyloxy)-2-methylpentanoyl]-1,3-oxazolan-2-one 
• 250679-52-8 (3S)-3-[((tert-butyl)dimethylsilyl)oxy]-1-[(1S,5R)-10,10-dimethyl-3,3-dioxido-3-thia-4-azatricyclo[5.2.1.0^1.5]dec-4-yl]-4,4-dimethylheptan-1,5-dione 
• 279227-06-4 (3S,6R,7S,8S)-11-(benzyloxy)-1,3,7-tris{[(tert-butyl)dimethylsilyl]oxy}-4,4,6,8-tetramethylundecan-5-one 
• 279227-07-5 (3S,6R,7S,8S)-11-(benzyloxy)-3,7-bis{[(tert-butyl)dimethylsilyl]oxy}-hydroxy-4,4,6,8-tetramethylundecan-5-one 
• 279227-08-6 (3S,6R,7S,8S)-11-(benzyloxy)-3,7-bis{[(tert-butyl)dimethylsilyl]oxy}-4,4,6,8-tetramethyl-5-oxoundecanal 
• 279227-05-3 (3S,6R,7S,8S)-11-(benzyloxy)-1,3,7-trihydroxy-4,4,6,8-tetramethylundecan-5-one 
• 279227-04-2 (4R,5S,6S)-9-(benzyloxy)-2-[(4S)-2,2-dimethyl-1,3-dioxan-4-yl]-5-hydroxy-2,4,6-trimethylnonan-3-one 
• 250679-53-9 (5S)-5-{[(tert-butyl)dimethylsilyl]oxy}-7-hydroxy-4,4-dimethylheptan-3-one 
• 187283-45-0 (S)-3-((tert-butyldimethylsilyl)oxy)-4,4-dimethyl-5-oxoheptanoic acid 
• 185148-95-2 2-[(4S)-2,2-dimethyl-1,3-dioxan-4-yl]-2-methyl-3-pentanon 
• 106921-60-2 2,2-dimethyl-3-oxopentanal 
• 279227-20-2 (2S)-5-benzyloxy-2-methyl-1-pentanal 

Relevant articles and documents

Total synthesis of 12,13-desoxyepothilone B (Epothilone D)

A highly convergent total synthesis of 12,13-desoxyepothilone B (4, Epothilone D) is described involving the coupling of vinyl iodide (5) and olefin (6). Key steps in the synthesis are the introduction of chirality at C15 via highly enantioselective lipas

Synthesis and biological evaluation of highly potent analogues of Epothilones B and D

A series of new epothilone B and D analogues incorporating fused hetero-aromatic side chains have been prepared. The synthetic strategy is based on olefin 3 as the common intermediate and allows variation of the side-chain structure in a highly convergent and stereoselective manner. Epothilone analogues 1a-d and 2a-d are more potent inhibitors of cancer cell proliferation than the corresponding parent epothilones B orD. (C) 2000 Elsevier Science Ltd.