279237-43-3

Upstream product

• 191544-73-7 4-[5-(2-aminoethyl)imidazol-1-ylmethyl]benzonitrile 
• 173774-50-0 N-Boc-piperazine-2-amidoanhydride 

Downstream Products

• 281197-51-1 N₂-[2-[1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl]ethyl]-N₄-phenyl-1,2(R)-piperazinecarboxamide 

Relevant academic research and scientific papers

PIPERAZINE DERIVATIVES AS FARNESYL PROTEIN TRANSFERASE INHIBITORS

Disclosed are compounds of the formula: wherein R13 represents an imidazole ring; R14 represents a carbamate, urea, amide or sulfonamide group, and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.

NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl-protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.

Inhibitors of farnesyl-protein transferase

Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.