173774-50-0

Upstream product

• 173774-48-6 (R)-piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 281197-78-2 bis(1,1-dimethyl) 2(R)-[[[2-(phenylmethoxy)ethyl]amino]carbonyl]-1,4-piperazinedicarboxylate 
• 279236-97-4 2(R)-[[[3-(1H-imidazol-1-yl)propyl](phenylmethyl)amino]carbonyl]piperazine 
• 279237-41-1 N₄-(1,1-dimethylethyloxycarbonyl)-N₂-[2-[1-[(4-chlorophenyl)methyl]-1H-imidazol-5-yl]ethyl]-1,2(R)-piperazinecarboxamide 
• 279237-42-2 N₄-(1,1-dimethylethyloxycarbonyl)-N₂-[2-[1-(phenylethyl)-1H-imidazol-5-yl]ethyl]-1,2(R)-piperazinecarboxamide 
• 944469-31-2 C₂₃H₃₃N₅O₃ 
• 279236-60-1 C₃₀H₄₁N₇O₄ 
• 124-38-9 carbon dioxide 
• 279237-31-9 1,1-dimethyl 1-[(cyclohexylamino)carbonyl]-2(R)-[[[2-(2-methyl-1H-benzimidazol-1-yl)ethyl]amino]carbonyl]-4-piperazinecarboxamide 
• 281195-40-2 1,1-dimethylethyl-1-[(cyclohexylamino)carbonyl]-2(R)-[[[[2-[1-(4-fluorophenyl)methyl]-1H-imidazol-5-yl]ethyl]amino]carbonyl]-4-piperazinecarboxylate 
• 279236-45-2 C₂₅H₄₂N₆O₄ 
• 279237-37-5 4-(1,1-dimethylethyl) 1-(phenylmethyl)-2(R)-[[[2-(2,4-dimethyl-1H-imidazol-1-yl)ethyl]amino]carbonyl]-1,4-piperazinedicarboxamide 
• 279237-99-9 4-(1,1-dimethylethyl) 1-(phenylmethyl)-2(R)-[[[2-(2,5-dimethyl-1H-imidazol-1-yl)ethyl]amino]carbonyl]-1,4-piperazinedicarboxamide 
• 281197-81-7 C₂₅H₃₄N₆O₆ 
• 279237-43-3 N₄-(1,1-dimethylethyloxycarbonyl)-N₂-[2-[1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl]ethyl]-1,2(R)-piperazinecarboxamide 

Relevant academic research and scientific papers

PIPERAZINE DERIVATIVES AS FARNESYL PROTEIN TRANSFERASE INHIBITORS

Disclosed are compounds of the formula: wherein R13 represents an imidazole ring; R14 represents a carbamate, urea, amide or sulfonamide group, and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.

NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl-protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.

FARNESYL PROTEIN TRANSFERASE INHIBITORS

Disclosed are compounds of formula (1.0), wherein R represents a cyclic moiety to which is bound an imodazolylalkyl group; R represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.