27943-07-3

Basic information

• Product Name: 5-CYCLOPROPYL-2H-1,2,3,4-TETRAAZOLE
• Synonyms: ART-CHEM-BB B020831;5-CYCLOPROPYL-2 H-TETRAZOLE;5-CYCLOPROPYL-2H-1,2,3,4-TETRAAZOLE;AKOS B020831;5-CYCLOPROPYLTETRAZOLE;2H-tetrazole, 5-cyclopropyl-;5-cyclopropyl-2H-1,2,3,4-tetrazole;5-cyclopropyl-2H-tetraazole
• CAS NO: 27943-07-3
• Molecular Formula: C₄H₆N₄
• Molecular Weight: 110.12
• Mol File: 27943-07-3.mol

Chemical Properties

• Melting Point: 152-154°C
• Boiling Point: 284.2°Cat760mmHg
• Flash Point: 142.8°C
• Appearance: /
• Density: 1.46g/cm³
• Vapor Pressure: 0.00302mmHg at 25°C
• Refractive Index: 1.634
• PKA: 5.06±0.10(Predicted)
• CAS DataBase Reference: 5-CYCLOPROPYL-2H-1,2,3,4-TETRAAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CYCLOPROPYL-2H-1,2,3,4-TETRAAZOLE(27943-07-3)
• EPA Substance Registry System: 5-CYCLOPROPYL-2H-1,2,3,4-TETRAAZOLE(27943-07-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 27943-07-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
CP4TA is utilized as a crucial intermediate in the synthesis of various pharmaceuticals and agrochemicals, owing to its unique chemical properties and structural composition.
Used in Energetic Materials and Propellants:
Recognized for its high thermal stability and explosive characteristics, CP4TA is employed in the development of energetic materials and propellants, where its properties contribute to the performance and safety of these applications.
Used in Medical Research:
CP4TA is studied for its potential as an antihypertensive and antidiabetic agent, indicating its possible use in the medical field to address cardiovascular and metabolic health conditions.

InChI:InChI=1/C4H6N4/c1-2-3(1)4-5-7-8-6-4/h3H,1-2H2,(H,5,6,7,8)

Upstream product

• 5500-21-0 cyclopropropanecarbonitrile 

Downstream Products

• 922711-41-9 2-[(5-cyclopropyl-1H-tetrazol-1-yl)methyl]-4-fluoroaniline 

Relevant articles and documents

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.

PYRIDINE DERIVATIVE AS ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF

Disclosed in the present invention are a compound as shown in formula (II), a tautomer or a pharmaceutically acceptable salt thereof, and also disclosed is the use thereof in preparing a drug for treating an ASK1-associated disease.

Efficient synthesis of tetrazole hemiaminal silyl ethers via three-component hemiaminal silylation

An efficient route to construct 2,5-disubstituted tetrazole hemiaminal silyl ethers via one-pot three-component hemiaminal silylation of 5-substituted tetrazoles, aldehydes, and silyl triflates was developed. Diverse 2,5-disubstituted tetrazole hemiaminal silyl ethers were obtained with 37?:?63->99?:?1 regioisomeric ratios. The regioselectivities of this reaction were significantly affected by steric hindrance and the conjugation effects of substitutions on the 5-position of tetrazoles.

Green synthetic approach to 5-substituted-1h-tetrazoles via recycle and reuse of tributyltin chloride

A simple, safe and efficient process for the recycle of tributyltin chloride from tributyltin hydroxide is developed and its reuse in the synthesis of 5-substituted-1H-tetrazoles is successfully demonstrated, which paved a way to reduce the toxic tin waste significantly. Recycling of tributyltin chloride is possible over six cycles without loss of its activity.

FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE

The invention relates to compounds of formula (I) for the regulation of phosphoinositides 3-kinases activity and related diseases.

CHEMICAL COMPOUNDS

Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein -N-HET is, for example, formula (Ic) or (If) wherein R1 is, for example, halogen or a (1-4C)alkyl group which is substituted by one subs