27948-40-9Relevant academic research and scientific papers
Separation of (S)-(-)-3-methyl-2-pyrrolidinone as an inclusion complex with (R)-(+)-4,4′,6,6′-tetrachloro-2,2′-bis(hydroxydiphenylmethyl) -1,1′-biphenyl host and its X-ray structural study
Le Roex, Tanya,Nassimbeni, Luigi R.,Toda, Fumio
, p. 77 - 79 (2008/09/19)
By inclusion complexation with the chiral host compound (R)-(+)-4,4′,6,6′-tetrachloro-2,2′-bis(hydroxydiphenylmethyl) -1,1′-biphenyl, racemic 3-methyl-2-pyrrolidinone was resolved and its (S)-(-)-enantiomer was isolated as a 1:1 inclusion complex, which crystallises in the orthorhombic crystal system in the space group P212 121 (a = 14.1163(2) A, b = 14.7140(3) A, c = 17.2025(3) A). By the inclusion complexation, the keto-enol equilibrium of the guest was frozen and the keto-form was isolated in a pure form. By X-ray structural study of the complex, the guest molecule included was elucidated to be the keto-form and its absolute configuration was determined to be (S).
Optical resolution of cyclic amides by inclusion in dehydrocholic acid
Bortolini, Olga,Fogagnolo, Marco,Fantin, Giancarlo,Medici, Alessandro
, p. 206 - 207 (2007/10/03)
Dehydrocholic acid serves as an effective chiral host for the resolution of several five-, six-, and seven-membered cyclic amides by inclusion.
Asymmetric synthesis of 3-substituted pyrrolidones via α-alkylation of a chiral non-racemic γ-lactam
Baussanne, Isabelle,Travers, Catherine,Royer, Jacques
, p. 797 - 804 (2007/10/03)
3-Alkyl pyrrolidones 9 were synthesized in good yield and high diastereoselectivity by α-alkylation of the new chiral non-racemic lactam 8 derived from (R)-(-)-phenylglycinol. After debenzylation and introduction of an electron-withdrawing group, 3-methylpyrrolidone 10 is easily hydrolyzed in a basic medium to produce γ-aminobutyric acid (GABA) analogue 13.
Optically Active 4,4',6,6'-Tetrachloro-2,2'-bis(hydroxydiphenylmethyl)biphenyl As a Host for Optical Resolution and Chiral Shift Reagent
Toda, Fumio,Toyotaka, Ritsuji,Fukuda, Hideji
, p. 303 - 306 (2007/10/02)
The title biphenyl derivative was found to be useful as a host for optical resolution and as a chiral shift reagent for the determination of the optical purity and the absolute configuration of a wide variety of chiral compounds.
