279674-19-0

Upstream product

• 10049-08-8 ruthenium(III)chloride 
• 279674-33-8 4′-(4-phenylphenyl)-2,2′:6′,2″-terpyridine 

Relevant academic research and scientific papers

Red and blue luminescent metallo-supramolecular coordination polymers assembled through π-π interactions

The use of π-stacking interactions to control the aggregation of photo-active metal centres is explored through the design of bis(2,2′;6′,2″-terpyridyl) metal complexes functionalised with biphenyl 'tails'. Aryl-aryl interactions control the aggregation of the metal complexes into polymetallic arrays in the solid state. Cobalt(n), ruthenium(n), nickel(n), copper(n), zinc(n) and cadmium(n) bis-ligand complexes and a mixed ligand ruthenium(n) complex have been structurally characterised. The solid-state structures are dependent on which units dominate the π-stacking. For cobalt, ruthenium, nickel and copper, biphenylene-biphenylene interactions lead to linear rod-like arrays, while for the group 12 d10 ions zinc and cadmium, biphenylene-pyridyl interactions lead to two-dimensional sheets. The addition of the biphenylene tail has favourable effects on the photophysical-properties of the complexes which exhibit room temperature red (ruthenium) or blue (zinc and cadmium) luminescence, both in solution and the solid state. The Royal Society of Chemistry 2000.

Labile ruthenium(II) complexes with extended phenyl-substituted terpyridyl ligands: Synthesis, aquation and anticancer evaluation

Ruthenium complexes have been considered as promising substitutes for cisplatin in cancer chemotherapy. However, novel ruthenium-based therapies are faced with some limitations, such as unimpressive cytotoxicity toward solid tumors. Herein, we designed and synthesized phenyl-substituted terpyridyl ruthenium(ii) complexes ([Ru(tpy)(bpy)Cl]+ (Ru1), [Ru(phtpy)(bpy)Cl]+ (Ru2) and [Ru(biphtpy)(bpy)Cl]+ (Ru3)) which exhibited distinctly different anticancer activity. Ru1-Ru3 all underwent moderate aquation in buffer solution and this process was significantly inhibited by high chloride concentration. Cancer cells were found to readily uptake the relatively hydrophobic Ru3, as quantified using inductively coupled plasma mass spectrometry (ICP-MS). Ru1 was found to be non-cytotoxic (IC50 > 100 μM) while Ru3 exhibited very promising cytotoxicity on both two-dimensional (2D) cancer cell monolayers and 3D MCTSs. An antiproliferative assay revealed that Ru3 significantly inhibited cellular DNA replication which ultimately induced apoptosis of cancer cells.