2798-22-3

Upstream product

• 1168-42-9 5,6,7,4'-tetramethoxyflavone 
• 93993-77-2 1-(2,5-dihydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)propenone 
• 41929-26-4 1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(4-methoxyphenyl)propenone 
• 3420-72-2 2'-hydroxy-4,4',6'-trimethoxychalcone 
• 169130-06-7 8-Benzyloxy-5-hydroxy-6,7-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one 
• 19103-54-9 5-hydroxy-4',6,7-trimethoxyflavone 

Downstream Products

• 2798-20-1 gardenin B 
• 481-53-8 tangeritin 
• 577-26-4 NSC₇₆₉₈₈ 

Relevant academic research and scientific papers

Regioselective hydroxylation of 2-hydroxychalcones by dimethyldioxirane towards polymethoxylated flavonoids

The flavone nucleus is part of a large number of natural products and medicinal compounds. In this presentation the novel regioselective hydroxylation of hydroxyarenes with DMD is described. The results showed further that flavonoids with 5-hydroxy group were selectively oxyfunctionalized at the para-position C8 carbon atom by DMD. Finally, according to this methodology, the naturally occurring isosinensetin, tangeretin, sinensetin, nobiletin, natsudaidain, gardenin B, 3,3′,4′,5,6,7,8- heptamethoxyflavone, quercetin and its derivatives were synthesized.

SYNTHESIS OF 5,8-DIHYDROXY-6,7-DIMETHOXYFLAVONES AND REVISED STRUCTURES FOR SOME NATURAL FLAVONES

Six 5,8-dihydroxy-6,7-dimethoxyflavones and three 8-hydroxy-5,6,7-trimethoxyflavones were synthesized from 2',5'-dihydroxy-3',4',6'-trimethoxyacetophenone by adapting the selective O-alkylation and dealkylation, and the differentiation between the flavones and their isomeric 6-hydroxyflavones was clarified by 1H NMR and UV spectra.Four natural flavones proposed as 5,8-dihydroxy-6,7-dimethoxyflavones, must have other structures and three are shown to be isomeric 5,7-dihydroxy-6,8-dimethoxyflavones.A flavone, isolated from Helichrysum, is revised to the isomeric 7-hydroxy-5,6,7-trimethoxyflavone,