1168-42-9Relevant articles and documents
Inhibitory effects of 5,6,7-trihydroxyflavones on tyrosinase
Gao, Hong,Nishida, Jun,Saito, Shizuka,Kawabata, Jun
, p. 86 - 97 (2007)
Baicalein (1), 6-hydroxyapigenin (6), 6-hydroxygalangin (13) and 6-hydroxykaempferol (14), which are naturally occurring flavonoids from a set of 14 hydroxyflavones tested, exhibited high inhibitory effects on tyrosinase with respect to L-DOPA, while each of the 5,6,7-trihydroxyflavones 1, 6, 13 or 14 acted as a cofactor to monophenolase. Moreover, 6-hydroxykaempferol (14) showed the highest activity and was a competitive inhibitor of tyrosinase compared to L-DOPA. 5,6,7-Trihydroxyflavones 1, 6, 13 or 14 showed also high antioxidant activities. Hence, we conclude that the 5,6,7-trihydroxy-flavones are useful as good depigmentation agents with inhibitory effects in addition to their antioxidant properties.
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Rao et al.
, p. 227 (1970)
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Robinson,Schwarzenbach
, p. 822,826 (1930)
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Pharmacokinetics and Metabolites of 12 Bioactive Polymethoxyflavones in Rat Plasma
Chen, Hongping,Ding, Haiyan,Hu, Yuan,Li, Dan,Liu, Youping,You, Qiang
, p. 12705 - 12716 (2021/11/17)
Polymethoxyflavones (PMFs) are a subgroup of flavonoids possessing various health benefits. 3,5,7,4′-Tetramethoxyflavone (1), 5,6,7,4′-tetramethylflavone (2), 3,7,3′,4′-tetramethoxyflavone (3), 5,7,3′,4′-tetramethoxyflavone (4), 5-hydroxy-3,7,2′,4′-tetramethoxyflavone (5), 3,5,7,2′,4′-pentamethoxyflavone (6), 5-hydroxy-3,7,3′,4′-tetramethoxyflavone (7), 3-hydroxy-5,7,3′,4′-tetramethylflavone (8), 3,5,7,3′,4′-pentamethoxyflavone (9), 5-hydroxy-3,7,3′,4′,5′-pentamethoxyflavone (10), 3-hydroxy-5,7,3′,4′,5′-pentamethoxyflavone (11), and 3,5,7,3′,4′,5′-hexamethoxylflavone (12) were 12 bioactive and available PMFs. The aim of this study was to investigate the pharmacokinetic, metabolite, and antitumor activities as well as the structure-pharmacokinetic-antitumor activity relationships of these 12 PMFs to facilitate further studies of their medicinal potentials. The cytotoxicity of PMFs with a hydroxy group toward HeLa, A549, HepG2, and HCT116 cancer cell lines was generally significantly more potent than that of PMFs without a hydroxy group. Compounds 5, 7, 8, 10, and 11 were all undetectable in rat plasma, while compounds 1-4, 6, 9, and 12 were detectable. Both the number and position of hydroxy and methoxy groups played an important role in modulating PMF pharmacokinetics and metabolites.
Synthesis method of scutellarein
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Paragraph 7-10, (2019/01/08)
The invention provides a synthesis method of scutellarein, aiming at solving the problems in the prior art that the yield of chemically synthesized scutellarein is relatively low and a dangerous reagent is used in a synthesis process. The synthesis method comprises the following steps: step 1) taking ethyl acetoacetate and p-anisoyl chloride as raw materials and synthesizing ethyl 3-(4-methoxyphenyl)-3-oxopropanoateethyl p-anisoyl acetate; step 2) synthesizing 5,6,7,4'-tetramethoxy flavone through the ethyl 3-(4-methoxyphenyl)-3-oxopropanoateethyl p-anisoyl acetate and 3,4,5-trimethoyphenol; step 3) removing methyl from the 5,6,7,4'-tetramethoxy flavone to obtain a scutellarein crude product; step 4) purifying the scutellarein crude product to finally obtaining a high-content scutellareinrefined product.
