2799-17-9

Usage

Uses

Used in Pharmaceutical Industry:
(S)-(+)-1-Amino-2-propanol is used as an intermediate in the synthesis of various pharmaceutical compounds, particularly those requiring chiral centers. Its ability to form stable complexes with other molecules makes it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, (S)-(+)-1-Amino-2-propanol is used as a building block for the synthesis of chiral pesticides and other agrochemicals. Its chiral nature allows for the creation of more targeted and effective products with reduced environmental impact.
Used in Cosmetics:
(S)-(+)-1-Amino-2-propanol is used as an emulsifying agent in the cosmetics industry. Its ability to form stable emulsions helps create products with improved texture, stability, and performance.
Used in Drycleaning Industry:
As a component in drycleaning soaps, (S)-(+)-1-Amino-2-propanol aids in the cleaning process by helping to dissolve and remove stains from fabrics.
Used in Textile Industry:
In the textile industry, (S)-(+)-1-Amino-2-propanol is used in the production of soluble textile oils, which help to lubricate and protect fibers during manufacturing processes.
Used in Wax Removal:
(S)-(+)-1-Amino-2-propanol is utilized as a component in wax removers, helping to dissolve and remove wax from various surfaces.
Used in Metal-Cutting Oils:
As a component in metal-cutting oils, (S)-(+)-1-Amino-2-propanol improves the lubrication and cooling properties of the oil, enhancing the efficiency and longevity of cutting tools.
Used in Emulsion Paints:
In the paint industry, (S)-(+)-1-Amino-2-propanol is used as an emulsifying agent to create stable emulsions, resulting in improved paint performance and application properties.
Used in Plastics Industry:
As a plasticizer, (S)-(+)-1-Amino-2-propanol is used to increase the flexibility and workability of plastics, making them more suitable for various applications.
Used in Insecticides:
In the agricultural sector, (S)-(+)-1-Amino-2-propanol may be used in the preparation of chiral insecticides, which can target specific pests while minimizing harm to beneficial insects and the environment.
Used in Chemical Synthesis:
(S)-(+)-1-Amino-2-propanol may be used in the preparation of S-(+)-1-(2,3-naphthalimido)-2-propanol, a compound with potential applications in various industries, including pharmaceuticals and materials science.

InChI:InChI=1/C3H9NO/c1-3(5)2-4/h3,5H,2,4H2,1H3/t3-/m0/s1

Upstream product

• 78-96-6 3-amino-2-propanol 
• 2043-43-8 (S)-(-)-lactamide 
• 75-56-9 methyloxirane 
• 945494-57-5 C₅H₉NO₃ 
• 111688-36-9 (S)-5-methyloxazolidin-2-one 
• 109849-51-6 (S)-(+)-1-Phthalimido-2-propanol 

Downstream Products

• 53636-17-2 (S)-1-dimethylamino-2-propanol 
• 120524-56-3 (2R,3S,4R,5R)-2-Hydroxymethyl-5-[6-((S)-2-hydroxy-propylamino)-2-phenylamino-purin-9-yl]-tetrahydro-furan-3,4-diol 
• 83647-99-8 (2R)-2-methylaziridine 
• 88879-96-3 (2'S)-2,2-dimethyl-5-hydroxy-7-pentyl-4-(2'-hydroxypropylimino)-4H-2,3-dihydrobenzopyran 
• 157182-48-4 (+)-2-Methanandamide 
• 203638-99-7 (4S,5R)-4-((S)-2-Hydroxy-propylcarbamoyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 213335-53-6 [(R)-1-((S)-2-Hydroxy-propylcarbamoyl)-2-phenyl-ethyl]-methyl-carbamic acid tert-butyl ester 
• 1026560-36-0 [(R)-2-(3,4-Difluoro-phenyl)-1-((S)-2-hydroxy-propylcarbamoyl)-ethyl]-methyl-carbamic acid tert-butyl ester 
• 16888-96-3 (2S)-N,O-dibenzoyl-1-amino-2-propanol 

Relevant academic research and scientific papers

Preparation method of chiral 1-amino-2-propanol

The invention provides a preparation method of chiral 1-amino-2-propanol, which comprises the following steps: carrying out ring-opening reaction on trifluoroacetamide and chiral epoxypropane to generate an intermediate product I; and carrying out hydrolysis reaction on the intermediate product I to obtain the chiral 1-amino-2-propanol. According to the preparation method, the target product can be obtained through a two-step reaction, so that the preparation process of chiral 1-amino-2-propanol is greatly simplified; and the raw materials trifluoroacetamide and chiral epoxypropane are cheap and easily available, the reaction process is simple, the operation is convenient, harsh reaction conditions such as high temperature and high pressure are not needed, complex purification, post-treatment and chiral resolution operations are also not needed, and the obtained target product has high purity, high yield and high optical activity, and is suitable for large-scale industrial preparation.

HIV INTEGRASE INHIBITORS

The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.

METHOD FOR PRODUCING OPTICALLY ACTIVE 2-HYDROXY ESTER AND NOVEL INTERMEDIATE COMPOUND

Disclosed is a method for producing an optically active 2-hydroxy ester, comprising selectively esterifying one enantiomer of a racemic 2-hydroxy ester in a solvent containing a catalyst such as tetramisole or benzotetramisole, and a carboxylic acid anhydride, or a carboxylic acid anhydride and a carboxylic acid. In particular, in the case where the solvent contains a carboxylic acid anhydride, but does not contain a carboxylic acid, as the carboxylic acid anhydride, a carboxylic acid anhydride containing a tertiary or quaternary carbon atom in the a-position is used. On the other hand, in the case where the solvent contains a carboxylic acid anhydride and a carboxylic acid, as the carboxylic acid, a carboxylic acid containing a tertiary or quaternary carbon atom in the a-position is used.

Asymmetric hydroformylation of vinyl acetate: Application in the synthesis of optically active isoxazolines and imidazoles

Equation Presented (R)- and (S)-2-(Acetyloxy)-propanal were prepared [93.8% ee, 102 b/l for (R), 96.9% ee, 149 b/l for (S)] via asymmetric hydroformylation of vinyl acetate on a 150-180 g scale and were used as the starting materials in the synthesis of chiral isoxazoline and imidazole derivatives which proceeded without racemization of the chiral center.

Highly Enantioselective Asymmetric Hydrogenation of α-Phthalimide Ketone: An Efficient Entry to Enantiomerically Pure Amino Alcohols

A new type of α-phthalimide ketones was hydrogenated in excellent enantioselectivity by using a Ru-(C3-TunePhos) complex as the catalyst. Up to 10000 turnovers have been achieved in more than 99% ee in the hydrogenation reaction. A dynamic kinetic resolution study for the synthesis of threonine was performed, and high anti selectivity (>97:3) was observed for the first time. An efficient method to synthesize enantiomerically pure amino alcohols has been developed. Copyright

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS

The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed

Resolution of β-aminoalcohols and 1,2-diamines using fractional crystallization of diastereomeric salts of dehydroabietic acid

(S)-(+)-1-Amino-3-phenyloxy-2-propanol, (R)-(-)-2-amino-1-phenylethanol, (S)-(+)-1-amino-2-propanol, (1S,2S)-(+)-2-aminocyclohexanol and (1S,2S)-(+)-1,2-diaminocyclohexane were resolved using dehydroabietic acid. It was shown that good to high enantiomeric purity, between 81～>99% ee, was obtained and that dehydroabietic acid could be easily and efficiently recovered in a reusable form.

Process for the selective enzymatic hydroxylation of aldehydes and ketones

A process for the selective enzymatic hydroxylation of aldehydes and ketones using chiral anchor-protective groups.

A novel highly stereoselective synthesis of chiral 5- and 4,5-substituted 2-oxazolidinones

A novel highly stereoselective synthesis of chiral mono- and bicyclic 4- and 4,5-substituted 2-oxazolidinones starting from β-keto esters was developed. After bioreduction with S. cerevisiae the resulting homochiral β-hydroxy esters are transformed into their hydrazides. Treatment with NaNO2/H+ then furnishes 2-oxazolidinones in high e.e. (～99%) and d.e. (>99%). The ring formation proceeds via a highly concerted sextet rearrangement with full retention of configuration at the stereocentres. Enantiopure 1,2-amino alcohols can subsequently be obtained by saponification of the 2-oxazolidinone products.

Synthesis of Peptidosulfinamides and Peptidosulfonamides: Peptidomimetics Containing the Sulfinamide or Sulfonamide Transition-State Isostere

Synthetic routes are described toward the preparation of α- as well as β-substituted aminoethanesulfinyl chlorides, starting from either an aldehyde or from an amino acid derivative.The sulfinyl chlorides are used as building blocks for the preparation of homochiral α- or β-substituted sulfinamide and sulfonamide transition-state isosteres.The methodology has been applied to the synthesis of peptidosulfonamide peptidomimetics such as a hapten needed for the generation of antibodies and potential HIV protease inhibitors.In addition, the β-substituted aminoethanesulfinyl chlorides were used as building blocks for the preparation of a tetrapeptidosulfonamide, which can be considered as a biopolymer mimetic, employing a repetition of a cycle of three reactions: coupling of the sulfinyl chloride to the N-terminus of the growing peptidosulfonamide, oxidation to the sulfonamide, and deprotection of the N-terminus.