2799-93-1Relevant academic research and scientific papers
Synthesis and crystallographic study of N'-(1-benzylpiperidin-4-yl) acetohydrazide
Nichol, Gary S.,Vardanyan, Ruben,Hruby, Victor J.
experimental part, p. 961 - 964 (2011/10/03)
As part of a study into new Fentanyl-derived opioid compounds with potent analgesic activity and reduced side effects the starting material title compound, C14H21N3O (1), was synthesized and characterized by NMR spectroscopy and single-crystal X-ray diffraction. The crystal structure is monoclinic Cc with unit cell parameters a = 14.1480(3) A, b = 14.1720(4) A, c = 27.6701(7) A, β = 96.956(1)°, α = γ = 90°. The compound has crystallized with four crystallographically unique molecules in the asymmetric unit; each molecule has a very similar conformation and an analysis of the structure shows that although all four unique molecules overlay very well there is no evidence of pseudo-symmetry which would relate the molecules in the higher symmetry space group C2/c. The crystal packing consists of two separate hydrogen bonded chains which are linked together to form a thick 2D structure in the ab plane. Index Abstract: The compound N'-(1-benzylpiperidin-4-yl)acetohydrazide crystallizes with four crystallographically unique molecules in the asymmetric unit; each molecule has a very similar conformation but there is no evidence of pseudo-symmetry.[Figure not available: see fulltext.]
