27991-81-7Relevant academic research and scientific papers
Transkarbams as transdermal permeation enhancers: Effects of ester position and ammonium carbamate formation
Novotny, Michal,Hrabálek, Alexandr,Jan??ová, Barbora,Novotny, Jakub,Vávrová, Kate?ina
scheme or table, p. 2726 - 2728 (2010/08/04)
Transkarbam 12, an ammonium carbamate formed by the reaction of dodecyl 6-aminohexanoate with carbon dioxide, is a highly active, broad-spectrum, nontoxic, and nonirritant transdermal permeation enhancer. It probably acts by a dual mechanism: a part of its activity is associated with the carbamic acid salt and/or its decomposition in the acidic stratum corneum. The ammonium ester thereby released is an active enhancer species as well, and its activity highly depends on the position of the ester group.
Transformations of higher terpenoids: IV. Synthesis and spectral parameters of glycyrrhetinic acid derivatives containing amino acid fragments
Petrenko,Petukhova,Shakirov,Shul'ts,Tolstikov
, p. 982 - 995 (2007/10/03)
New glycyrrhetinic acid derivatives containing amino acid and amino ester fragments were synthesized as potential biologically active substances. NMR spectra of the newly synthesized compounds were studied, and assignment of signals of the C8 and C14 carbon atoms in the terpenoid fragment was refined.
