28004-56-0

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-5-(2-METHOXYPHENYL)-1,3,4-THIADIAZOLE is used as a potential active pharmaceutical ingredient for its broad-spectrum antimicrobial properties, targeting a range of bacteria and fungi, making it a candidate for the development of new antibiotics and antifungal agents.
Used in Anti-inflammatory and Analgesic Applications:
In the pharmaceutical industry, 2-AMINO-5-(2-METHOXYPHENYL)-1,3,4-THIADIAZOLE is utilized as an anti-inflammatory and analgesic agent, leveraging its ability to reduce inflammation and alleviate pain, which can be beneficial in the treatment of various inflammatory and painful conditions.
Used in Oncology:
2-AMINO-5-(2-METHOXYPHENYL)-1,3,4-THIADIAZOLE is employed as a potential anti-tumor and anti-cancer agent, with research indicating its capacity to inhibit tumor growth and exhibit anti-cancer properties, making it a promising candidate for cancer therapy and drug development.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-AMINO-5-(2-METHOXYPHENYL)-1,3,4-THIADIAZOLE serves as a key component for further research and drug discovery, given its diverse pharmacological properties and potential for the development of novel therapeutic agents.

Upstream product

• 135-02-4 ortho-anisaldehyde 
• 79-19-6 thiosemicarbazide 
• 579-75-9 2-Methoxybenzoic acid 
• 2290-65-5 trimethylsilyl isothiocyanate 
• 7466-54-8 2-methoxybenzoylhydrazine 
• 4334-73-0 2-[(2-methoxyhenyl)methylene]hydrazinecarbothioamide 

Downstream Products

• 40288-19-5 2-Chloro-5-(2-methoxy-phenyl)-[1,3,4]thiadiazole 
• 176380-41-9 [1-Furan-2-yl-meth-(E)-ylidene]-[5-(2-methoxy-phenyl)-[1,3,4]thiadiazol-2-yl]-amine 
• 172669-75-9 2-{1-[(E)-5-(2-Methoxy-phenyl)-[1,3,4]thiadiazol-2-ylimino]-ethyl}-phenol 
• 172669-65-7 2-{[(E)-5-(2-Methoxy-phenyl)-[1,3,4]thiadiazol-2-ylimino]-methyl}-phenol 
• 176380-37-3 4-[(E)-5-(2-Methoxy-phenyl)-[1,3,4]thiadiazol-2-ylimino]-pentan-2-one 
• 176380-34-0 [5-(2-Methoxy-phenyl)-[1,3,4]thiadiazol-2-yl]-[1-methyl-2-phenyl-eth-(E)-ylidene]-amine 
• 172669-70-4 1-{[(E)-5-(2-Methoxy-phenyl)-[1,3,4]thiadiazol-2-ylimino]-methyl}-naphthalen-2-ol 
• 1374152-11-0 C₁₆H₁₁N₃O₂SSe 
• 1227624-50-1 C₁₀H₉N₃O₂S 

Relevant academic research and scientific papers

Aryl or heteroaryl substituted thiadiazole compound and antibacterial application thereof

The invention belongs to the technical field of medicines, and particularly relates to an aryl or heteroaryl substituted thiadiazole compound, a preparation method and application thereof as an antibacterial drug. The compound is represented by formula (1

N-(5-phenyl-1, 3, 4-thiadiazole-2-yl) benzamide compound

The invention belongs to the technical field of medicines, relates to a compound with antitumor activity and a specific chemical structure, and in particular relates to an N-((6, 7-dimethoxyquinoline-4-yl) oxy) methyl)-N-(5-phenyl-1, 3, 4-thiadiazole-2-yl) benzamide compound and a preparation method and an application thereof. The structural general formula of the compound is shown in the specification, wherein an R group is mono-substituted or double-substituted phenyl, fluorophenyl, chlorphenyl, bromophenyl, benzyl, benzyloxy, benzene nitro or trifluoromethyl substituted at 2-position, 3-position or 4-position. Pharmacological studies show that the compound provided by the invention has a relatively remarkable proliferation inhibition effect on HER-2 positive breast cancer cells SK-Br-3, the effect is obviously superior to that of HER-2 negative breast cancer cells MCF-7, the compound can be used for preparing antitumor drugs, and a new way is opened up for deep research and development of tumor drugs in the future. The preparation method provided by the invention is simple and feasible, relatively high in yield and easy for large-scale production.

METHODS OF TREATING EPILEPSY USING THE SAME

The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same for the treatment of seizures, epilepsy related conditions, epilepsy-related syndrome, and the like as described herein.

Synthesis of (1,3,4-thiadiazol-2-yl)-acrylamide derivatives as potential antitumor agents against acute leukemia cells

A lead compound with the (1,3,4-thiadiazol-2-yl)-acrylamide scaffold was discovered to have significant cytotoxicity on several tumor cell lines in an in-house cell-based screening. A total of 60 derivative compounds were then synthesized and tested in a CCK-8 cell viability assay. Some of them exhibited improved cytotoxic activities. The most potent compounds had IC50 values of 1–5 μM on two acute leukemia tumor cell lines, i.e. RS4;11 and HL-60. Flow cytometry analysis of several active compounds and detection of caspase activation indicated that they induced caspase-dependent apoptosis. It was also encouraging to observe that these compounds did not have obvious cytotoxicity on normal cells, i.e. IC50 > 50 μM on HEK-293T cells. Although the molecular targets of this class of compound are yet to be revealed, our current results suggest that this class of compound represents a new possibility for developing drug candidates against acute leukemia.

Novel 1,3,4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies

A series of 15 novel 1,3,4-thiadiazole amide derivatives containing a protocatechuic acid moiety were synthesized and structurally characterized. In addition, the corresponding imino (4) and amino (5) analogues of a phenyl-substituted 1,3,4-thiadiazole am

COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME

The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same.

PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles

A highly efficient method for the synthesis of thiadiazole derivatives via intramolecular oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents is developed. The protocol can be carried out smoothly and provides a variety of thiadiazole derivatives in moderate to excellent yields. Graphical Abstract: A highly efficient method for the synthesis of thiadiazole derivatives via PhI-catalyzed intramolecular oxidative coupling of thiosemicarbazide has been developed.

One-pot synthesis of 5H-1,3,4-thiadiazolo[3,2-a] pyrimidin-5-one derivatives

A novel and efficient one-pot method has been developed for the synthesis of 2-substituted-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5- one derivative by the combination of [3 + 3] cycloaddition, reduction, deamination reactions. The fused heterocyclic compoun

Mild and convenient one-pot synthesis of 2-amino-1,3,4-thiadiazoles using trimethylsilyl isothiocyanate (TMSNCS)

A novel and efficient one-pot method has been developed for the synthesis of 2-amino-1,3,4-thiadiazoles using various carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS). In situ preparation of various thiosemicarbazides by the reaction

An efficient synthesis of novel bis-1,3,4-thiadiazolyl-carbamate derivatives based on deoxycholic acid under microwave irradiation

An easy and efficient method for the synthesis of novel deoxycholic acid bis-1,3,4-thiadiazol-carbamate derivatives under microwave irradiation has been developed. Twelve new methyl 3α,12α-bis-[(5-aryl-1,3,4-thiadiazol-2- yl) carbamoyloxy]-cholan-24-oates