28004-70-8

Upstream product

• 2565-30-2 formyl chloride 
• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 68-12-2 N,N-dimethyl-formamide 
• 121-98-2 methyl 4-methoxybenzoate 

Downstream Products

• 4602-17-9 2-(4-methoxyphenyl)-1,3,4-thiadiazole 
• 70187-22-3 3-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole 

Relevant academic research and scientific papers

TBSOTf-promoted versatile N-formylation using DMF at room temperature

Hydrazides and amines were N-formylated by DMF in the presence of tert-butyldimethylsilyl triflate (TBSOTf) at room temperature, in good to excellent yields.

Synthesis and analgesic activity in 1,2,4-triazole series

Derivatives of 1,2,4-triazole have been synthesized. Several methods of synthesis were used and the analgetic and antiinflammatory properties of the products obtained were studied. Structural requirements for analgetic activity were specified. Certain compounds show a high degree of analgetic activity. One of them, RU 39813, has been chosen for extended pharmacological study.