70187-22-3

Usage

InChI:InChI=1/C15H13N3O/c1-19-14-9-7-12(8-10-14)15-17-16-11-18(15)13-5-3-2-4-6-13/h2-11H,1H3

Upstream product

• 28004-70-8 4-methoxy-benzoic acid N'-formyl-hydrazide 
• 62-53-3 aniline 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 342631-66-7 C₁₅H₁₅N₃OS 
• 123-11-5 4-methoxy-benzaldehyde 
• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 121-98-2 methyl 4-methoxybenzoate 

Relevant academic research and scientific papers

Synthesis of 1,2,4-Triazoles via Oxidative Heterocyclization: Selective C-N Bond over C-S Bond Formation

The higher propensity of C-N over C-S bond forming ability was demonstrated, through formal C-H functionalization during the construction of 4,5-disubstituted 1,2,4-triazole-3-thiones from arylidenearylthiosemicarbazides catalyzed by Cu(II). However, ster

Novel 4H-1,2,4-triazole derivatives

Compounds selected from the group consisting of 4H-1,2,4-triazoles of the formula STR1 wherein R1, R2, R3 and R4 may be in different positions of the benzene ring, R1, R3 and R4 are individually selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, --CF3, --NO2, --NH2 and NH--AlK and STR2 R2 is selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, halogen, --CF3, --NO2, --NH2, --NH--AlK and STR3 and AlK, AlK1 and AlK2 are alkyl of 1 to 4 carbon atoms or R1 and R2 together and/or R3 and R4 together are methylenedioxy, R is selected from the group consisting of ethyl, --CH2 --COOH and CH2 --COOAlK3 and AlK3 is alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts, with the proviso that R1, R2, R3 and R4 are not all hydrogen having a remarkable analgesic activity and a novel method for their preparation.

Synthesis and analgesic activity in 1,2,4-triazole series

Derivatives of 1,2,4-triazole have been synthesized. Several methods of synthesis were used and the analgetic and antiinflammatory properties of the products obtained were studied. Structural requirements for analgetic activity were specified. Certain compounds show a high degree of analgetic activity. One of them, RU 39813, has been chosen for extended pharmacological study.

4,5-Bis(aryl)-4H-1,2,4-triazole derivatives and analgesic use

Novel 4H-1,2,4-triazoles of the formula STR1 wherein R1, R2, R3 and R4 may be in different positions of the benzene rings and are individually selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, --CF3, --NO2, --NH2 and --NH--AlK and STR2 and AlK, AlK1 and AlK2 are alkyl of 1 to 4 carbon atoms or R1 and R2 together and/or R3 and R4 together are methylenedioxy, R is selected from the group consisting hydrogen, alkyl of 1 to 4 carbon atoms, --CH2 --COOH and --CH2 --COOAlK3 and AlK3 is alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having a remarkable analgesic activity and a novel method for their preparation.