28006-93-1

Upstream product

• 5673-07-4 2,6-dimethoxytoluene 
• 7149-92-0 2,4-dimethoxy-3-methylbenzaldehyde 

Downstream Products

• 946860-98-6 S-bromo-2-hydroxy-4-methoxy-3-methylbenzaldehyde 
• 116589-11-8 Methanesulfonic acid (1R,2R,9S,9aS)-5,8-bis-benzyloxy-9-benzyloxymethyl-2-(dimethoxy-phosphorylamino)-7-methoxy-6-methyl-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl ester 
• 116589-12-9 C₃₇H₄₁N₂O₇P 
• 116589-08-3 Methanesulfonic acid (1R,2S,9S,9aS)-5,8-bis-benzyloxy-9-benzyloxymethyl-1-hydroxy-7-methoxy-6-methyl-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indol-2-yl ester 
• 116611-91-7 5,8-Dibenzyloxy-9β-benzyloxymethyl-2,3,9,9a-tetrahydro-7-methoxy-6-methyl-1H-pyrrolo<1,2-a>indole-1α,2α-diol 
• 116589-20-9 4,7-Dibenzyloxy-8β-benzyloxymethyl-1,1aα,2,8,8aβ,8b-hexahydro-6-methoxy-5-methylazirino<2',3';3,4>pyrrolo<1,2-a>indole 
• 116589-07-2 5,8-Dibenzyloxy-9β-benzyloxymethyl-9,9aβ-dihydro-7-methoxy-6-methyl-3H-pyrrolo<1,2-a>indole 
• 88088-70-4 9β-Benzyloxymethyl-9,9aβ-dihydro-7-methoxy-6-methyl-3H-pyrrolo<1,2-a>indole-5,8-dione 
• 116589-17-4 9-Benzyloxymethyl-7-methoxy-6-methyl-3H-pyrrolo[1,2-a]indole-5,8-dione 
• 116589-04-9 2(1-Benzyloxymethylpenta-2,4-dienyl)-3-fluoro-4,6-dimethoxy-5-methylphenol 
• 116589-05-0 2-(1-Benzyloxymethylpenta-2,4-dienyl)-3-fluoro-6-methoxy-5-methyl-1,4-benzoquinone 
• 109034-93-7 3-fluoro-4,6-dimethoxy-1-(methoxymethoxy)-5-methyl-2-(2,4-pentadienyl)benzene 
• 105104-18-5 5-fluoro-2,4-dimethoxy-3-methylphenyl 2,4-pentadienyl ether 
• 105104-11-8 1-Bromo-2,4-dimethoxy-5-methoxymethoxy-3-methyl-benzene 

Relevant academic research and scientific papers

New Drug Delivery System for Crossing the Blood Brain Barrier

New ubiquinol analogs are disclosed, as well as methods of using these compounds to deliver drug moieties to the body.

Synthesis of 9a-Deoxymitomycin Congeners

The protected mitosane (23) is prepared in stereospecific manner.The key reactions included in the synthetic scheme are (i) Lewis acid-mediated Claisen-type rearrangement of the penta-2,4-dienyl aryl ether (10) to the penta-2,4-dienylphenol (11), (ii) the regioselective incorporation of the alkoxymethyl group at the 1-position of the pentadienyl side-chain in the protected pentadienylhydroquinone (12), and (iii) the stereospecific copper-catalysed double cyclization of the azido(penta-2,4-dienyl)quinone (15) to the 3H-pyrroloindole-5,8-dione (16) in one step.Subsequent stereospecific introduction of the aziridine ring furnishes the target compound (23).

Lewis Acid Mediated Claisen-Type Rearrangement of Aryl Dienyl Ethers

Rearrangement of aryl pentadienyl ethers in the presence of BF3*OEt2 affords pentadienyl phenols in good yields without formation of the corresponding rearranged products.The mechanism of this rearrangement was studied by deuterium labeling and cross-coupling reactions.The scope and limitations of the rearrangement are discussed.